Study on Protective Effect of Yinzhihuang Injection on Hepatic Cell Damage Caused by Carbon Tetrachloride

REN Yong-shen; ZHANG Ping; YAN dan; DUAN Hui-juan; LI Zheng-ming; XIAO Xiao-he

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Study on Protective Effect of Yinzhihuang Injection on Hepatic Cell Damage Caused by Carbon Tetrachloride

更新时间：2024-09-23

- Study on Protective Effect of Yinzhihuang Injection on Hepatic Cell Damage Caused by Carbon Tetrachloride
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 18, Pages: 115-118(2010)
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- Published：2010
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REN Yong-shen, ZHANG Ping, YAN dan, et al. Study on Protective Effect of Yinzhihuang Injection on Hepatic Cell Damage Caused by Carbon Tetrachloride[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 115-118.
DOI：

REN Yong-shen, ZHANG Ping, YAN dan, et al. Study on Protective Effect of Yinzhihuang Injection on Hepatic Cell Damage Caused by Carbon Tetrachloride[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 115-118. DOI：

摘要

目的 :研究茵栀黄注射液对四氯化碳(CCl4)所致大鼠肝细胞损伤的保护作用。方法 :采用CCl4熏蒸法造成体外肝细胞损伤模型

观察不同厂家生产的茵栀黄注射液与复方茵陈注射液及其有效成分黄芩苷及香豆素的保护作用。结果 :各厂家生产的茵栀黄注射液均能能显著降低丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST) 及丙二醛(MDA) 的含量

提高谷胱甘肽-过氧化物酶(GSH-Px)的活性

降酶作用以复方茵陈注射液样品的作用最强。结论 :茵栀黄注射液及其主要有效成分黄芩苷及香豆素对CCl4所致大鼠肝细胞损伤具有保护作用

各厂家正常样品药效作用具有较好的一致性。

Abstract

Objective: To study the protective effect of Yinzhihuang Injection on hepatic cell damage caused by Carbon tetrachloride (CCl4) in vitro. Method: CCl4 fumigation method was adopted to duplicate hepatic cell damage in vitro

and the protective effect of Yinzhihuang Injection and Fufang Yinchen Injection and their main active ingredients

baicalin and coumarin

from different companies were investigated. Result: The ALT

AST and MDA of damaged cells could be decreased and GSH-Px could be elevated by Yinzhihuang Injections from different factories

and the strongest protective effect was originated by Fufang Yinchen Injection. Conclusion: Both Yinzhihuang Injection and their main active ingredients

baicalin and coumarin

could prevent the hepatic cell damage caused by CCl4 in vitro

and the protective effect of normal samples from different companies had good consistency agreed with each other.

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Related Author

XIAO Xiao-he1

LI Zheng-ming1

DUAN Hui-juan1

YAN Dan1

REN Yong-shen1

ZHANG Ping1

Pei-fen YANG

Qiu-shan LIN

Related Institution

China Military Institute of Chinese Materia Medica,302 Military Hospital

Pharmacy College,Chengdu University of Traditional Chinese Medicine

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine

Hunan University of Chinese Medicine

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