Determination Content of Isofraxidin and Rosmarinic Acid in Qingre Xiaoyanning Capsules by HPLC

LI Xiong; YANG Liu; ZENG Xing; DENG Yuan-hui; GAO Zhi-neng

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Determination Content of Isofraxidin and Rosmarinic Acid in Qingre Xiaoyanning Capsules by HPLC

更新时间：2024-09-23

- Determination Content of Isofraxidin and Rosmarinic Acid in Qingre Xiaoyanning Capsules by HPLC
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 11, Pages: 53-55(2010)
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- Published：2010
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LI Xiong, YANG Liu, ZENG Xing, et al. Determination Content of Isofraxidin and Rosmarinic Acid in Qingre Xiaoyanning Capsules by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 53-55.
DOI：

LI Xiong, YANG Liu, ZENG Xing, et al. Determination Content of Isofraxidin and Rosmarinic Acid in Qingre Xiaoyanning Capsules by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 53-55. DOI：

摘要

目的: 建立同时测定消炎宁胶囊中异秦皮啶与迷迭香酸含量的高效液相色谱分析方法。方法: 色谱柱Waters XBridge C18柱(4.6 mm×250 mm

5 μm);流动相为乙腈-0.1%磷酸(21[DK1]∶79)

等度洗脱;检测波长340 nm;流速1 mL[DK1]·min-1。结果: 异秦皮啶在0.32～3.2 μg

迷迭香酸在0.256 6～2.566 μg与峰面积呈良好的线性关系(r=0.999 8

0.999 9);平均加样回收率分别为97.3%

98.9%

RSD分别为1.6%

1.3%。结论: 该法简便、重复性好、各成分分离良好

建立的方法可更有效地控制清热消炎宁胶囊的质量。

Abstract

Objective: To establish an HPLC method for simultaneous determination of isofraxidin and rosmarinic acid in Qingre Xiaoyanning Capsules. Method: A HPLC method was used with a Waters XBridge C18 column(4.60 mm×250 mm

5 μm) and acetonitrile-0.1% phosphoric acid (21[DK1]∶79) as the mobile phase.The flow rate was 1.0 mL·min-1 and the detection wavelength was 340 nm. Result: The linear ranges of isofraxidin and rosmarinic acid were 0.32-3.2 μg(r=0.999 8) and 0.256 6-2.566 μg (r=0.999 9)

respectively. The average recoveries (n =6) were 97.3% (RSD 1.6%) and 98.9% (RSD 1.3%)

respectively. Conclusion: This HPLC method is simple

accurate and relilable

and can be used for the quality control of Qingre Xiaoyanning Capsules.

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Related Author

LI Xiong1

YANG Liu1

ZENG Xing1

DENG Yuan-hui1

GAO Zhi-neng2

WANG Hui

ZHANG Zhen-qiu

GENG Fang

Related Institution

Second Affiliated Hospital,Guangzhou University of Traditional Chinese Medicine

Guangdong Pharmaceutical University

Harbin Normal University

Jiamusi College,Heilongjiang University of Chinese Medicine

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