Study on Drug Releasing Property of Triptolide Microemulsion Gel

GUAN Yong-mei; ZHAO Yi; CHEN Li-hua; WANG Sen; ZHU Wei-feng; LIU Hong-ning

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Study on Drug Releasing Property of Triptolide Microemulsion Gel

更新时间：2024-01-04

- Study on Drug Releasing Property of Triptolide Microemulsion Gel
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 17, Pages: 1-3(2010)
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- Published：2010
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GUAN Yong-mei, ZHAO Yi, CHEN Li-hua, et al. Study on Drug Releasing Property of Triptolide Microemulsion Gel [J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 1-3.
DOI：

GUAN Yong-mei, ZHAO Yi, CHEN Li-hua, et al. Study on Drug Releasing Property of Triptolide Microemulsion Gel [J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 1-3. DOI：

摘要

目的 :对雷公藤微乳凝胶的体外释药性能进行考察。方法 :采用扩散池法

分别以半透膜和小鼠皮肤为透过介质

考察雷公藤微乳凝胶的透皮性能和释药速率。结果 :雷公藤微乳凝胶体外释药规律以一级模型拟合较好

透皮速率约为2.6 μg ·cm-2 ·h-1。结论 :雷公藤微乳凝胶中雷公藤甲素的体外透皮速率小于体外释放速率

表明该制剂属于缓释制剂。

Abstract

ObJective: To investigate the drug-releasing efficiency of triptolide microemulsion gel in vitro. Method: Franz diffusion cell was used to investigate the percutaneous absorption of the triptolide with semipermeable membrane and mice skin as the percutaneous barrier. Result: The experimental equation fitting for drug release characteristics of triptolide microemulsion gel was the first-order model in vitro

and the percutaneous speed was 2.6 μg ·cm-2 ·h-1. Conclusion: The transdermal speed of triptolide was less than the drug-releasing speed in triptolide microemulsion gel; triptolide microemulsion gel was the controlled releasing preparation.

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