ObJective: To evaluate the preventative and therapeutical effect of Xiaoer Feire Kechuan oral solution on the immunocompromised mice infected by influenza virus A (H1N1). Method: ICR mice were inJected cyclophosphamide to establish immunocompromised mice model

at the same day

the mice were infected by influenza A (H1N1) by nasal drops. The lung index

death rate

death protection rate and life prolongation were observed; The virus load in lungs was detected by real-time RT-PCR and the level of immune factors in blood serum were detected by ELISA. Result: With preventative and therapeutical treatment of Xiaoer Feire Kechuan oral solution

the lung index

death rate and the virus load in lung tissues of immunocompromised mice which were infected by influenza virus FM1 strain and PR8 strain decreased significantly

while the life time of immunocompromised mice was prolonged by the oral solution and CD4/CD8 ratio in serum increased significantly. Conclusion: Xiaoer Feire Kechuan oral solution could inhibit virus pneumonia in immunocompromised mice caused by influenza virus A(H1N1)significantly.