Objective: To study the protective effect of aqueous extract of Erzhi Pill (AEEP) on acute hepatic injury induced by carbon tetrachloride(CCl4) in mice. Method: Sixty Kunming mice were randomly divided into six groups: the normal group

the model group

bifendate group(150 mg ·kg-1)

high AEEP group(19.8 g ·kg-1)

middle AEEP group(13.2 g ·kg-1) and low AEEP group(6.6 g ·kg-1). The treatment groups were orally administered once per day for 7 d separately

whereas the normal and model groups were orally administered with saline. Except normal rats

all the other rats were injected intraperitoneally CCl4 20 mL ·kg-1 once. The rats were sacrificed 16 h after CCl4administration. Serum and liver samples were collected for analysis. The acute hepatic injury model was prepared by CCl4injected intraperitoneally. Then

the therapeutic effects of AEEP on the model were evaluated by the activity determination of serum alanine aminotransferase and asparate aminotransferase (ALT and AST)

superoxide dismutase(SOD)and the content of malondialdehyde (MDA)in liver

and the hepatic pathohistological changes following the treatment. Result: The activities of ALT and AST and the MDA content in liver was significantly increased and the activity of SOD was largely inhibited in the animals of modeling group. Following the treatment with AEEP

ALT and AST activities and MDA content were significantly reduced and SOD activity was obviously increased in the mice of treatment group. Furthermore

AEEP could ameliorate the hepatic pathological changes. Conclusion: AEEP have protective effects on acute hepatic injury induced by CCl4in mice.