Immunoregulative Action and Inhibitive Effect of  on Tumor Cells

LUO Chun-li

您当前的位置：

首页 >

文章列表页 >

Immunoregulative Action and Inhibitive Effect of on Tumor Cells

更新时间：2024-01-04

- Immunoregulative Action and Inhibitive Effect of on Tumor Cells
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 13, Pages: 155-158(2010)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2010
- 稿件说明：
移动端阅览
LUO Chun-li. Immunoregulative Action and Inhibitive Effect of on Tumor Cells[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 155-158.
DOI：

LUO Chun-li. Immunoregulative Action and Inhibitive Effect of on Tumor Cells[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 155-158. DOI：

摘要

目的 :运用中药血清药理学的研究方法

研究余甘子对S180荷瘤小鼠肿瘤存活率、主要免疫器官及红细胞免疫调节能力的影响。方法 :余甘子采用鲜果榨汁经冷冻干燥保存。建立小鼠肿瘤模型

模型小鼠随机分组

小鼠末次给药后摘眼球取血

分离红细胞、淋巴细胞

进行肿瘤红细胞淋巴细胞混合花环实验;观察不同剂量给药组对小鼠肿瘤抑制率及脾、胸腺指数的影响。结果 :与模型对照组比较

余甘子大剂量组红细胞促淋巴细胞黏附肿瘤细胞能力及抑制肿瘤存活率具极显著差异性;与阳性对照组比较

各剂量组对免疫器官的影响均具显著差异性。结论 :余甘子在抑制肿瘤生长的同时

对免疫器官有极好的保护作用。

Abstract

Objective: To investigate the effect of Phyllanthus emblica on survival rate and immunoregulation capability in main immune organs and erythrocyte of S180 tumour-burdened mice with serum pharmacology method for evaluation of Chinese herbs. Method: P. emblica fresh fruits were juiced and then stored after freeze-drying. Mice tumor model of S180 burdened was established. Mice were randomly grouped into model group and treatment groups with different doses of P. emblica. Erythrocytes and lymphocytes were separated from blood samples after the last administration of the herb. The mixed rosette test was carried out with tumor erythrocytes and lymphocytes. The effect of different dose of P. emblica was evaluated by inhibition rate of the tumor

spleen index and thymus index. Result: Compared with model group P. emblica of high dose group had significant elevated adherence of lymphocytes to tumor cells promoted by erythrocytes

inhibition for survival rate of tumor cells. The three dosage groups all showed significant regulative effect for immune organs

compared with positive control group. Conclusion: P. emblica inhibits proliferation of tumor and improves immunity function of the hosts.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Ameliorative Effect of Gramine on 2，4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice

Research Progress in Pharmacology of Lianhua Qingwen Preparation

Effects of Lingguizhugan Decoction on T-lymphocyte Subset and the Activity of Interleukin-2 in Immunosuppuressed Mice Induced by Cyclophosphamide

Phamacodynamic Studies of Zangqingguo Houpian

Effect of on Immune Hepatic Fibrosis in Liver Fibrosis Rats Caused by Porcine Serum(Ⅱ)

Related Author

Miao JIANG

Jia-kui WANG

Chun-jie WU

Guang-ping ZHANG

Yun-hang GAO

Zu-guang YE

WANG Tong-sheng

WU Hua-qiang

Related Institution

School of Pharmacy， Chengdu University of Traditional Chinese Medicine， Key Laboratory of Standardization for Chinese Herbal Medicine， Ministry of Education， National Key Laboratory Breeding Base of Systematic Research， Development and Utilization of Chinese Medicine Resources

Institute of Chinese Material，China Academy of Chinese Medical Sciences

Key Laboratory of New Drug Delivery System of Chinese Meteria Medica,Jiangsu Provincial Academy of Chinese Medicine,Key Laboratory of Drug Release System of Oral Traditional Chinese Mealicine

Guangxi College of TCM,Nanning 530001,China: 2.Nanning Hospital of TCM

The First Hospital,Guangxi College of TCM

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰