Objective: To study the effects of Modified Xionggui Decoction(MXD) on protection from cerebral ischemia injury and its influence on hemorheological parameters in rats. Method: Seventy of Wistar rats were undergone right middle cerebral artery occlusion (MCAO) according the method of intraluminal thread

then were randomly divided into 5 groups. Four groups were administered MXD (0.38

0.76

1.52 g ·kg-1) and Tongmai Keli (2.7 g ·kg-1) respectively. MCAO model group and sham-operation control group of fifteen rats were administered with the same volume of water. The neurologic findings were scored

hemorheological parameters were measured

and the size of cerebral infarction was determined by TTC-stained method

and histopathologic changes were observed. Result: MXD and Tongmai Keli significantly improved neurologic function after administered drugs for 5 days. MXD and Tongmai Keli significantly reduced blood viscosity of high shear rate

reduced blood viscosity and plasma viscosity

and significantly lessened the size of cerebral infarction and lightened histopathologic changes after administered for 7 days. Conclusion: MXD may improve the obstruction of neurologic function

and protect brain from ischemia injury. The effect of MXD might be related with improvement in hemorheological parameters.