Formulation and Process Optimization of Coptis Effect Components Pellets Prepared by Extrusion-spheronization

XIE Yan; HU Yong; MA Yue-ming; ZHANG Ning

您当前的位置：

首页 >

文章列表页 >

Formulation and Process Optimization of Coptis Effect Components Pellets Prepared by Extrusion-spheronization

更新时间：2024-01-04

- Formulation and Process Optimization of Coptis Effect Components Pellets Prepared by Extrusion-spheronization
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 16, Pages: 8-12(2010)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2010
- 稿件说明：
移动端阅览
XIE Yan, HU Yong, MA Yue-ming, et al. Formulation and Process Optimization of Coptis Effect Components Pellets Prepared by Extrusion-spheronization[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 8-12.
DOI：

XIE Yan, HU Yong, MA Yue-ming, et al. Formulation and Process Optimization of Coptis Effect Components Pellets Prepared by Extrusion-spheronization[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 8-12. DOI：

摘要

目的 :应用挤出滚圆法制备黄连效应组分微丸

研究中药微丸制备的新工艺。方法 :在考察黄连效应组分物理性质的基础上

用新型的挤出滚圆造粒机制备黄连效应组分微丸

采用单因素试验优化制剂处方及工艺条件

评价了微丸的粉体学性质、收率和体外溶出度。结果 :用挤出滚圆法制备的黄连效应组分微丸在15 min内体外溶出均达85%以上

且圆整度好

收率高。结论 :用挤出滚圆法可制备中药微丸

该工艺简便易行

制得的微丸圆整度好

收率高

体外释药迅速。

Abstract

Objective: To prepare Coptis effect components pellets by extrusion-spheronization and study the formulation and new technology process. Method: Based on the physical characters of Coptis effect components

the fast-release pellets of Coptis effect components were prepared by extrusion-spheronization. The formulation and process were studied by direct comparison. Then their characters were evaluated such as powder properties

yield

dissolution etc. Result: The active components could release more than 85% in 15 minutes and the pellets presented perfect sphericity and high yield. Conclusion: Extrusion-spheronization was suitable to produce Chinese herbal medicine pellets. The preparation process was simple and feasible. The spherical degree and yield were high

and active components could release quickly in vitro

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The Progress of Pellets

The Preparation of Compound Danshen Pellets by Using Centrifugal Granulator

Investigation of Release of 5-aminosalicylic Acid Colon-specific Osmotic Pump Pellets in Rats

Optimization and Difference Analysis of Preparation Technology for Blank Pellets Core with Four Kinds of Pharmaceutical Excipients by Centrifugal Granulation Method

Preparation of Saponins Liposome Pellets

Related Author

TONG Yan

REN Qian

LUO Xiao-jian

GUAN Yang

SUN Sha-sha

ZHANG Guo-song

LIN Ting-ting

ZHANG Jian-qin

Related Institution

Nationl Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine

Jiangxi University of Traditional Chinese Medicine, Nanchang 3300006

Jiangxi Renfeng Medicines & DRUG Co,Ltd

药固体制剂制造技术国家工程研究中心

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰