Objective: To investgate the efficacy of radioactive 125I seed implant brachytherapy for salivary malignancy. Method: Twelve patients with salivary malignancy were treated by radioactive 125I seed implanting. Eight patients’ tumors were completely resected by surgery. Two patients’ tumors were part resected by surgery. Two patients did not accept the surgery because they could not tolerate surgery. Result: All the patients were followed up for 2- 36 months. The volume of tumors for those with radioactive therapy and without surgery was reduced obviously. Two patients’ tumors were disappeared by partially surgery plus radioactive therapy. Eight patients who accepted complete operations had no local recurrence. The local control rate was 91%. Conclusion: The radioactive 125I seed implant brachytherapy for salivary malignancy is effective. But the long-term effects need further investigation.