Intervention of Huoxue Lishi Prescription in Rats Alcoholic Kidney Damage
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Intervention of Huoxue Lishi Prescription in Rats Alcoholic Kidney Damage
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 18, Pages: 187-189(2010)
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Published:2010
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QIU Hao, LV Xiao-yun, LIU Wen, et al. Intervention of Huoxue Lishi Prescription in Rats Alcoholic Kidney Damage[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 187-189.
DOI:
QIU Hao, LV Xiao-yun, LIU Wen, et al. Intervention of Huoxue Lishi Prescription in Rats Alcoholic Kidney Damage[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 187-189.DOI:
Intervention of Huoxue Lishi Prescription in Rats Alcoholic Kidney Damage
Objective: To study the effect of Huoxue Lishi prescription(HLP) on rats renal injury induced by alcohol. Method : The animal model of alcoholic renal injury was established with the method of direct intragastric infusion of ethanol and HLP. At the end of 4
8
12 weeks
the blood ureanitrogen(BUN)
and creatinine(Scr) were measured and the renal pathological changes were observed by HE staining and transmission electron microscope
respectively. Result : In HLP group
BUN and Cr were all decreased (P<0.05
P<0.01) and some pathological changes
such as hyperplasia of mesangium
interstitial infiltration of inflammatory cell
the degeneration of renal tubularepithelial cell and the dilatation of tubule appeared late and were attenuated as time progressed
compared with that of alcohol group(P<0.05). Conclusion : Huoxue Lishi prescription could inhibit rats renal injury induced by alcohol.