Preparation and  Dissolution of Genhuang Dispersible Tablet

XIN Rui-hua; LUO Yong-jiang; ZHENG Ji-fang; DENG Su-ping; WANG Gui-bo; LI Wei; HU Zhen-ying

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Preparation and Dissolution of Genhuang Dispersible Tablet

更新时间：2024-01-04

- Preparation and Dissolution of Genhuang Dispersible Tablet
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 16, Pages: 1-4(2010)
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- Published：2010
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XIN Rui-hua, LUO Yong-jiang, ZHENG Ji-fang, et al. Preparation and Dissolution of Genhuang Dispersible Tablet[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 1-4.
DOI：

XIN Rui-hua, LUO Yong-jiang, ZHENG Ji-fang, et al. Preparation and Dissolution of Genhuang Dispersible Tablet[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 1-4. DOI：

摘要

目的 :优选根黄分散片的处方工艺

并对其溶出行为进行考察。方法 :以崩解时限为考察指标

采用正交试验设计筛选出最佳处方

RP-HPLC测定根黄分散片中有效成分的含量

绘制其体外溶出曲线。结果 :优选出最佳处方:40%的微晶纤维素(MCC)为填充剂

15%的交联聚乙烯吡咯烷酮(PVPP)和7%的低取代羟丙基纤维素(L-HPC)为联合崩解剂

分散片可在3 min内完全崩解并且全部通过2号筛

在10 min时累积溶出度可达到99%以上。结论 :该工艺制备的分散片符合规定

可操作性强、重复性好、适合工业化生产的要求。

Abstract

Objective: To optimize the shaping technology of the Genhuang Dispersible Tables and study the release characteristics in vitro. Method: The orthogonal design was used to obtain the optimal formulation with the disintegration of tablets;dissolution method and RP-HPLC method were used to study the release curve in vitro. Result: The proportion of each adjuvant in the optimal formulation consisted of 40% MCC as bulking agent

15% PVPP and 7% L-HPC as disintegrant.The prepared dispersible tables could be totally disintegrated within three minutes and crossed No.2 sieve

which subjected to the Chinese pharmacopoeia.The percentage of dissolution was more than 99%. Conclusion: The dispersible tables were in accordance with the standard.The process was operable

repeatable and suitable to the batch manufacture.

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