Acute Toxicity of Volatile Oil from  in Rats and Mice

SUN Rong; WANG Li; YANG Qian; HUANG Wei; LV Li-li

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Acute Toxicity of Volatile Oil from in Rats and Mice

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- Acute Toxicity of Volatile Oil from in Rats and Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 11, Pages: 154-156(2010)
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- Published：2010
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SUN Rong, WANG Li, YANG Qian, et al. Acute Toxicity of Volatile Oil from in Rats and Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 154-156.
DOI：

SUN Rong, WANG Li, YANG Qian, et al. Acute Toxicity of Volatile Oil from in Rats and Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 154-156. DOI：

摘要

目的 :观察柴胡挥发油对大、小鼠的急性毒性反应

评价其安全性大小。方法: 分别给大、小鼠ig不同剂量的柴胡挥发油

观察急性毒性反应症状、体征、死亡时间和累计死亡率

用Bliss法分别计算半数致死量(LD50)及其95%可信限。结果: 柴胡挥发油给大、小鼠ig的急性毒性症状主要有:烦躁、异步态、心率加快、呼吸急促、连续性抽搐

柴胡挥发油给大、小鼠ig的LD50及其 95%可信限分别为2.081(1.759 9～2.461 3)mL·kg-1和3.118(2.872 4～3.391 2)mL·kg-1。结论: ig柴胡挥发油对大、小鼠ig可造成急性毒性损伤

有必要对柴胡挥发油的致毒成分、毒性机制、作用靶点等进行深入研究

以期为柴胡及其制剂的安全有效应用提供依据。

Abstract

Objective: To observe the actute toxicity of volatile oil from Bupleurum chinense in mice and rats and evaluate its safety. Method: Ig volatile oil from B. chinense of different dosages to mice and rats; the acute toxical symptoms

signs

death time and accumulated death rate were observed and the LD50 was calculated by Bliss method. Result: Restlessness

abnormal walking

accelerated heart rate

breathlessness

consecutive convulsion were the main acute toxical symptoms and signs caused by volatile oil from B. chinense ;the LD50 and its 95% confident limit of volatile oil of B. chinense to rats and mice are 2.081(1.759 9-2.461 3)mL·kg-1 and 3.118(2.872 4-3.391 2)mL·kg-1 differently. Conclusion: Ig volatile oil from B. chinense to rats and mice can cause acute toxical injury to them.The further study on toxical components

toxical cheminisms and toxical targets of volatile oil from B. chinense are need to do

so as to offer experimental basement for the safe and effective application of B. chinense and its preparation.

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Related Author

SUN Rong1

WANG Li2

YANG Qian2

HUANG Wei2

LV Li-li1

Yu-ping XIA

Chun-hua HE

Zi-shu CHAI

Related Institution

Shandong Academy of Chinense Medicine,The Pharmacology Department

Shandong University of Traditional Chinense Medicine

Guangxi University of Chinese Medicine

Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica

Guangxi Xian Zhu Chinese Medicine Technology Co.Ltd.

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