Objective: To observe the effects of Wuzi Yanzong Pill on the memory

immune function

anti-hypoxia and anti-fatigue in mice. Method: Wuzi Yanzong Pill was administered to ICR mice at oral doses of crude drug 0.6

1.2

2.4 g ·kg-1.The learning and memory ability in mice were tested by Morris water maze experiment.Carbon expurgation method and delayed allergy were used to determine the immune function.Fatigue and acute anoxia in mice were produced by swimming and hypoxia under normal pressure respectively and survival time was determined. Result: Compared with control group

the escape latency and swimming distance of all dose groups were shorter (P<0.05 or P<0.01).High dosage increased the expurgatory index(P<0.01)but all dose groups had no effect on swelling of ear.High and middle dosage significantly prolonged the survival time under hypoxia(P<0.01).High dosage prolonged the swimming time of mice(P<0.05). Conclusion: Wuzi Yanzong Pill has remarkable effect on enhancing the ability of learning and memory in ICR mice

improving the tolerance of hypoxia and fatigue

promoting non-specific immune function but has no effect on cellular immune function.