Objective: To observe the effect of four different treatments of traditional Chinese medicine on the rat model of myocardial hypertrophy induced by isoproterenol (ISO). Method: The rats were injected subcutaneously by 20

10

5 mg ·kg-1 ISO degressively and then 3 mg ·kg-1ISO as maintenance dose for 7 days to build the rat model of myocardial hypertrophy

Jinkui Shenqi Wan (JGSQ)

Buyang Huanwu Tang (BYHW)

Shengmai Yin(SMY) and Zhenwu Tang (ZWT) were given to the rats for 10 weeks as interventions and after that

the hemodynamics

cardiac output

heart mass index(HMI)

left ventricular mass index (LVMI) and serum level of ANP

BNP were observed. Result: Comparing with the model group

JGSQ and BYHW groups increased the hemodynamics LVSP

+dp/dtmax greatly and made a significant promotion to cardiac output ( P <0.05). At the mean time

HMI and LVMI decreased in these two groups as well as ANP and BNP ( P <0.05). ZWT and SMY group had no significant difference in decreasing the levels of ANP and BNP as well as the levels of HMI and LVMI. It showed decreased cardiac output and myocardial systolic function after treatment with ZWT and SMY ( P <0.05). Conclusion: We can improve the hemodynamic status of the rats to increase their cardiac output

inhibit the myocardial hypertrophy and reduce the level of neurohumoral factor by using the TCM therapeusis of warming kidney yang and benefiting qi

activating blood.