Metabomonics Study on Urine of Normal Rats Administered with Cinnamomi Cortex Water Extract
|更新时间:2024-01-04
|
Metabomonics Study on Urine of Normal Rats Administered with Cinnamomi Cortex Water Extract
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 17, Pages: 164-168(2010)
作者机构:
作者简介:
基金信息:
DOI:
CLC:
Published:2010
稿件说明:
移动端阅览
ZHANG Qi-yun, LI Bing-tao, XU Guo-liang, et al. Metabomonics Study on Urine of Normal Rats Administered with Cinnamomi Cortex Water Extract[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 164-168.
DOI:
ZHANG Qi-yun, LI Bing-tao, XU Guo-liang, et al. Metabomonics Study on Urine of Normal Rats Administered with Cinnamomi Cortex Water Extract[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 164-168.DOI:
Metabomonics Study on Urine of Normal Rats Administered with Cinnamomi Cortex Water Extract
ObJective: To investigate the changes of endogenous metabolites concentrations in the urine of normal rats administered with Cinnamomi Cortex water extract. Method: The administered group were administered orally with Cinnamomi Cortex water extract for 30 days.Urine was collected at 0
1
8
15
22
29 d after administration respectively and analyzed by LC/MS/MS.The acquired data were analyzed by PCA
OSC-PLS-DA. Result: After administration for 8 days
endogenous metabolites concentration in the urine of administered rats changed apparently. Through OSC-PLS-DA analysis
21 biomarkers were found. The identified biochemical effects of these biomarkers were associated with the pharmacological actions of Cinnamomi Cortex
including increased concentrations of CPA (18 ∶1(11Z)/0 ∶0)
gamma-linolenyl carnitine and decreased concentrations of deoxyuridine
CerP(d18 ∶1/22 ∶0). Conclusion: The administration of Cinnamomi Cortex water extract may change the cell signals and basic metabolism significantly in rat.