Effect of Peitu Yunkang Decoction on Threatened Abortion in Rats

DAI Shi-lin; CHEN Rong; XU Jing-sheng; WU Qi-nan

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Effect of Peitu Yunkang Decoction on Threatened Abortion in Rats

更新时间：2024-01-04

- Effect of Peitu Yunkang Decoction on Threatened Abortion in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 16, Pages: 113-115(2010)
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- Published：2010
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DAI Shi-lin, CHEN Rong, XU Jing-sheng, et al. Effect of Peitu Yunkang Decoction on Threatened Abortion in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 113-115.
DOI：

DAI Shi-lin, CHEN Rong, XU Jing-sheng, et al. Effect of Peitu Yunkang Decoction on Threatened Abortion in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 113-115. DOI：

摘要

目的 :观察培土孕康汤对大鼠先兆流产模型的治疗作用

探讨其作用机制。方法: 对妊娠大鼠以米非司酮合并米索前列醇建立先兆流产模型

分别用培土孕康汤12

3 g ·kg-1 ·d-1对妊娠大鼠灌胃治疗

黄体酮8 mg ·kg-1 ·d-1肌注治疗

同时设立模型对照组和正常妊娠组。妊娠14 d处死

考察保胎率、脏器系数

观察子宫卵巢组织的形态学变化

测定血清孕酮及β-绒毛膜促性腺激素(β-HCG)的含量。结果: 培土孕康汤12

3 g ·kg-1 ·d-1组均能显著提高先兆流产大鼠的血清β-HCG和孕酮含量及保胎率

对流产子宫损伤有显著疗效

减轻流产子宫的病理改变;其中在提高β-HCG含量及减轻子宫的损伤方面

培土孕康汤6 g ·kg-1组疗效优于黄体酮组;在提高孕酮含量和保胎率方面

培土孕康汤6 g ·kg-1 ·d-1组疗效与黄体酮组相当。结论: 培土孕康汤对于大鼠的先兆流产有较好的治疗作用

6 g ·kg-1 ·d-1组疗效最佳。

Abstract

Objective: To study the effects of Peitu Yunkang Decoction on abortion model of rat and to investigate the mechanism. Method: The abortion model was established in pregnant rats by giving mifepristone combined with misoprostol.The model was treated with 12

3 g ·kg-1 ·d-1 Peitu Yunkang Decoction and 8 mg ·kg-1 ·d-1 progesterone respectively for the model group and normal pregnancy group

normal saline of the same volume was given.All rats were sacrificed on the 14th day after pregnancy.Miscarriage rate

organ coefficient and morphological changes in uterine ovarian tissue were determined. Serum progesterone and β-Human chorionic gonadotropin(β-HCG) were also measured. Result: The group of 12

3 g ·kg-1 ·d-1 Peitu Yunkang Decoction increased the content of serum progesterone and β-HCG and the rate of anti-abortion significantly;The 6 g ·kg-1 ·d-1 Peitu Yunkang Decoction group had a better effect than the progesterone group in increasing β-HCG level and reducing the damage in the uterus. Conclusion: Peitu Yunkang Decoction has good effect for the treatment of rat model of threatened abortion

and the dose of 6 g ·kg-1 ·d-1 shows impressive effect.

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Related Institution

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