Objective: To optimize the ceramic membrane microfiltration purifying technology of the decoction of Yanshuning Compound. Method: Single factor test method was used to optimize the ceramic membrane aperture

according to indexes of the transfer rates of epigoitrin and harpagoside and removal ratio of impurity. And the ceramic membrane microfiltration refining effect was verified according to the vitro antibacterial activity. Result: The optimal ceramic membrane aperture was 200 nm. The import pressure was 0.2 MPa. When the liquid volume in the reservoir barrel was not enough to circulate

water with equal to the amount of the least circulation volume of the membrane filtration system was added once to the barrel. When the filtration volume was equivalent to the original

the filtration was ended. The transfer rates of epigoitrin

harpagoside and the removal ratio of impurity were 93.77%

82.67% and 24.64% respectively. There were no significant differences between MIC and MBC of the five kinds of pharyngitis bacteria of the ceramic membrane microfiltration refining fluid and the original fluid. Conclusion: The 200 nm ceramic membrane microfiltration technology was reasonable and feasible. It can be used as the purifying technology of the decoction of Yanshuning Compound.