Effects of Polysaccharides on Expression of Hippocampal NR2B in Aging Rats Induced by -gal
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Effects of Polysaccharides on Expression of Hippocampal NR2B in Aging Rats Induced by -gal
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 17, Pages: 147-150(2010)
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Published:2010
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YUAN Dian-Jie, ZHANG Yin-fa, YAO Chun-xiang. Effects of Polysaccharides on Expression of Hippocampal NR2B in Aging Rats Induced by -gal[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 147-150.
DOI:
YUAN Dian-Jie, ZHANG Yin-fa, YAO Chun-xiang. Effects of Polysaccharides on Expression of Hippocampal NR2B in Aging Rats Induced by -gal[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 147-150.DOI:
Effects of Polysaccharides on Expression of Hippocampal NR2B in Aging Rats Induced by -gal
ObJective: To explore effects of ganoderma lucidum polysaccharides on expression of hippocampal N-methyl-D-aspartate(NMDA) receptor 2B(NR2B) in aging rats induce by D-gal. Method: The permanent dosage (sc) of D-gal was applied to SD rats to establish the aging model. Different concentrations of Ganoderma lucidum polysaccharides were individually administrated (ig) for 10 days. The Morris water maze was applied to validate the learning in rats. With immunohistochemitry and Western Blotting
the expression of NR2B was detected on tissues of CA1 and CA3 regions in hippocampus in rats. Result: As compared with the model
rats treated with G. lucidum polysaccharides (125
100 mg ·kg-1) had longer durations of crossover platform and the persentage of swimming time in Ⅳ quadrant
as well as the increased expression of NR2B in hippocampus (P<0.01
P<0.01). Conclusion: G. lucidum polysaccharides would play important roles in promoting learning ability for aging rats induced by D-gal. The up-regulation of NR2B expression in hippocampus could be contributed to one of the related mechanisms.