Effects of Total Saponins from Balsam Pear on Insulin Resistance, Adiponectin and Leptin in Rat Model of Type 2 Diabetes
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Effects of Total Saponins from Balsam Pear on Insulin Resistance, Adiponectin and Leptin in Rat Model of Type 2 Diabetes
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 9, Pages: 177-179(2010)
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Published:2010
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LIU Yong-sheng, LI Xiao-kun, WANG Jin-ju. Effects of Total Saponins from Balsam Pear on Insulin Resistance, Adiponectin and Leptin in Rat Model of Type 2 Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(9): 177-179.
DOI:
LIU Yong-sheng, LI Xiao-kun, WANG Jin-ju. Effects of Total Saponins from Balsam Pear on Insulin Resistance, Adiponectin and Leptin in Rat Model of Type 2 Diabetes[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(9): 177-179.DOI:
Effects of Total Saponins from Balsam Pear on Insulin Resistance, Adiponectin and Leptin in Rat Model of Type 2 Diabetes
Objective: To explore the effect of total saponins from balsam pear(TSBP) on insulin resistance
adiponectin
leptin in rat model of type 2 diabetes. Method : The mice model of type 2 diabetes was established by eating food containing high sugar and fat and injected a samll dosage of streptozotocin (STZ). The levels of FBG
FINS
adiponectin and leptin in blood plasma were measured
and ISI was calculated. Finally
the effect of TSBP in rat model of type 2 diabetes was evaluated. Result : Compared with control group
TSBP groups and diformin tablet group could significantly decrease the level of FBG and FINS (P<0. 01)
and significantly rise ISI. TSBP groups could elevate the level of adiponectin
and decrease the level of leptin. Conclusion : TSBP can improve insulin resistance and has hypoglycemic action.