Study on Influencing Factors on Release of  Total Flavones from HPMC Matrix Tablets

YANG Xiu; XING Jian-guo; WANG Xin-chun; XUE Gui-peng; MA Zu-wen; REN Wen-dong

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Study on Influencing Factors on Release of Total Flavones from HPMC Matrix Tablets

更新时间：2024-09-23

- Study on Influencing Factors on Release of Total Flavones from HPMC Matrix Tablets
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 18, Pages: 6-9(2010)
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- Published：2010
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YANG Xiu, XING Jian-guo, WANG Xin-chun, et al. Study on Influencing Factors on Release of Total Flavones from HPMC Matrix Tablets[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 6-9.
DOI：

YANG Xiu, XING Jian-guo, WANG Xin-chun, et al. Study on Influencing Factors on Release of Total Flavones from HPMC Matrix Tablets[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 6-9. DOI：

摘要

目的 :制备香青兰总黄酮HPMC(羟丙甲纤维素)骨架片

考察主要活性成分田薊苷体外释药的影响因素。方法 :以HPMC为缓释骨架材料

采用湿法制粒压片法制备香青兰总黄酮骨架缓释片;测定香青兰总黄酮HPMC骨架片中主成分田薊苷在不同时间点的释放度

通过对体外释放曲线2

12 h累积释放度的综合评分 K 值及释放曲线相似因子 f 2的综合比较

考察影响田薊苷体外释药的因素。结果 :骨架材料HPMC的种类及乳糖和淀粉的比例是影响田薊苷体外释放的主要因素。骨架材料HPMC的用量及粘合剂等因素对田薊苷释放的影响不大。结论 :HPMC K15M 能有效控制香青兰总黄酮缓释骨架片中主成分的释放。

Abstract

Objective: Total flavones sustained-release tablets of Dracocephalum were prepared and the influencing factors on release of the tilianin of Dracocephalum were studied . Method: The Dracocephalum total flavones sustained-release tablets were compressed after wet granulating the extracts of Dracocephalum total flavones with HPMC. Then

the influencing factors on release of tilianin were investigated by determining release-rate of tilianin at different time to draw release curve and calculate K value (a kind of index comprehended with cumulative release at 2

12 h

respectively) and f2 (similar factorof release curve). Result : The main influencing factors on release-rate of tilianin were the type of HPMC and the ratio of starch to lactose; the amount of HPMC and adhesive were the secondary. Conclusion : The release of tilianin of Saussurea involucrate could be controlled effectively by selecting HPMC K15M as matrices.

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Related Author

REN Wen-dong1

MA Zu-wen1

XUE Gui-peng2

WANG Xin-chun1

XING Jian-guo2

YANG Xiu1

ZHANG Ya-hui

LIU Gui-hua

Related Institution

School of Pharmacy,Shihezi University

Xinjiang Institute of Meteria

The First Affiliated Hospital of Medical College

Tianjin Medical University

Tianjin Institute of Pharmaceutical Research

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