Researches of Flavonoids Components Changed Regularity in Different Compatibility of Dachengqi Decoction

XIE Zhen; WANG Shu-ling; JIANG Bin; ZENG Yuan-er

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Researches of Flavonoids Components Changed Regularity in Different Compatibility of Dachengqi Decoction

更新时间：2024-01-04

- Researches of Flavonoids Components Changed Regularity in Different Compatibility of Dachengqi Decoction
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 17, Pages: 57-59(2010)
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- Published：2010
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XIE Zhen, WANG Shu-ling, JIANG Bin, et al. Researches of Flavonoids Components Changed Regularity in Different Compatibility of Dachengqi Decoction[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 57-59.
DOI：

XIE Zhen, WANG Shu-ling, JIANG Bin, et al. Researches of Flavonoids Components Changed Regularity in Different Compatibility of Dachengqi Decoction[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(17): 57-59. DOI：

摘要

目的: 研究大承气汤在不同配伍方法中枳实黄酮类成分的变化规律。方法: 以君药大黄为核心

依次配伍其他3味中药(厚朴、枳实和芒硝)

进行不同配伍方法设计

共得到7种配伍组方。采用HPLC法测定不同配伍组中柚皮苷、橙皮苷的含量。结果: 大承气汤中枳实黄酮类成分在配伍环境中发生变化

经典煎法的柚皮苷和橙皮苷含量最高

分别为4.45%和1.16%。柚皮苷在0.168 5~1.164 8 μg有良好的线性关系(r=0.999 5)

平均回收率为98.20%

RSD为2.26%。结论: 大承气汤全方配伍后

在一定程度上能增加黄酮类成分含量的溶出率。所建立的柚皮苷、橙皮苷HPLC含量测定方法具有较好的专属性

可用于本方质量控制和配伍指标的测定。

Abstract

ObJective: To study the change of the content of active ingredient in Chinese material medicine. Method: Seven kinds of different compatibility of Dachengqi dceoctions were made when Rhei Radix et Rhizoma was decocted with other three drugs (Magnoliae Officinalis Cortex

Aurantii Fructus Immaturus and Natrii Sulfas)

then the quantitative analysis of naringin and hesperidin was determined by HPLC. Result: The flavonoid content was influenced by different compatibility of Dachengqi decoction. The contents of naringin and hesperidin were 4.45% and 1.16% in the traditional decoction

of which higher than those of in other decoctions. The linear range of naringin and hesperidin showed a good correlation from 0.168 5 to 1.684 8 μg(r=0.999 8)

and from 0.022 8 to 0.228 0 μg(r=0.999 5)

respectively. Their average recoveries were 98.85%(RSD=1.36%) and 98.20%(RSD=2.26%)

respectively. Conclusion: The flavonoid content was increased when all drugs were decocted. The HPLC method was well specified for determinantion of the contents of naringin and hesperidin

which could be applied to the quality control and active ingredient determination of compatibility of Dachengqi decoction.

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