Effect of pH on Transdermal Absorption Characteristics and Anti-inflammatory Activities of Brucine

LI Lei; Chen Jun; CAI Bao-chang; QI Yan

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Effect of pH on Transdermal Absorption Characteristics and Anti-inflammatory Activities of Brucine

更新时间：2024-09-23

- Effect of pH on Transdermal Absorption Characteristics and Anti-inflammatory Activities of Brucine
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 14, Pages: 1-3(2010)
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- Published：2010
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LI Lei, Chen Jun, CAI Bao-chang, et al. Effect of pH on Transdermal Absorption Characteristics and Anti-inflammatory Activities of Brucine[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(14): 1-3.
DOI：

LI Lei, Chen Jun, CAI Bao-chang, et al. Effect of pH on Transdermal Absorption Characteristics and Anti-inflammatory Activities of Brucine[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(14): 1-3. DOI：

摘要

目的: 考察不同pH对马钱子碱油水分配系数、体外经皮吸收性质与抗炎作用的影响。方法: 测定马钱子碱在pH 5

7.4

9的磷酸盐缓冲溶液(PBS)中的油水分配系数和体外经皮吸收速率;用二甲苯致小鼠耳壳肿胀

分别测定马钱子碱在pH 5

7.4

9的PBS中对肿胀的抑制作用。结果: 与pH 5相比

马钱子碱在pH 9的PBS中的油水分配系数和经皮吸收速率显著提高

分别为239.5倍和3.15倍

且对小鼠耳肿胀的抑制作用明显增强。结论: 增大pH可提高马钱子碱的油水分配系数及体外透皮性质

促进马钱子碱的经皮吸收

并且有利于抗炎作用的发挥。

Abstract

Objective: To study the influence of differenet pH on the oil-water partition co-efficient

transdermal absorption characteristics and the anti-inflammation effect of brucine solution. Method: The oil-water partition co-efficients and the permeation rates of brucine in pH 5

7.4 and 9 phosphate buffer solution(PBS) were measured; The effects of brucine in pH5

7.4 and pH 9 on the inflammatory edema of ear induced by xylol in mice were also determined. Result: The oil-water partition coefficient and permeation rate of brucine in pH 9 were(22.17±0.4) and (2.84±0.10)μg ·cm-2 ·h-1

which was almost 239.5 times and 3.15 times more than the corresponding data obtained under pH 5 PBS. The effect of inhibiting the inflammatory edema in the ear of mice induced by xylol was also markly increased under pH 9. Conclusion: The oil-water partition coefficient and transdermal absorption characteristics of brucine can be improved by increasing pH. which also markly promotes the anti-inflammatory activities of brucine.

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Related Author

LI Lei1

CHEN Jun1

CAI Bao-chang1

QI Yan1

LI Pengcheng

CHEN Tianyang

FANG Rong

ZHANG Anna

Related Institution

Nanjing University of Traditionanl Chinese Medicine

Jiangsu Key Laboratory of Chinese Medicine Processing

Engineering Center of State Ministry of Education for Standardization of Chinese Medicine Processing

The NATCM Third Grade Laboratory of TCM Preparations，Key Laboratory of Liver and Kidney Diseases （Ministry of Education）， Shanghai Key Laboratory of Traditional Chinese Clinical Medicine， Shuguang Hospital Affiliated to Shanghai University of TCM

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine （TCM）

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