Study on Pharmacokinetics and Bioequivalence of Syingopicroside Sustained-release Tablets in Rabbits
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Study on Pharmacokinetics and Bioequivalence of Syingopicroside Sustained-release Tablets in Rabbits
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 13, Pages: 4-6(2010)
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Published:2010
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LI Sheng-jin, LI Yong-ji, LV Shao-wa, et al. Study on Pharmacokinetics and Bioequivalence of Syingopicroside Sustained-release Tablets in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 4-6.
DOI:
LI Sheng-jin, LI Yong-ji, LV Shao-wa, et al. Study on Pharmacokinetics and Bioequivalence of Syingopicroside Sustained-release Tablets in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 4-6.DOI:
Study on Pharmacokinetics and Bioequivalence of Syingopicroside Sustained-release Tablets in Rabbits
Objective: To evaluate the pharmacokinetics and bioequivalence of syingopicroside self-sustained-release tablets in rabbits. Method: The blood concent ration of syingopicroside of 6 rabbits was determined by HPLC and the pharmacokinetic parameters were calculated with statistical moment and confidence interval after administered random crossover with single dose of self-sustained-release syingopicroside tablets (test pharmaceutics
T) or the self-common tablets (reference pharmaceutics
R). Result: The relative bioavailability of self-sustained-release syingopicroside tablets was 132.6%. In comparison with self-common tablets
the Tmax extended significantly and the peak was prolonged gentle; the 90% confidence interval of AUC0-t was 115.25%-144.44%; the 90% confidence interval of Cmax was 51.33%-78.53%. Conclusion: A good slow-release effect was found when compared test formulation with the reference reagent.
Study on Pharmacokinetics of Syringopicroside in Rabbits
Study on Pharmacokinetics and Bioequivalen of Multi-Absorption Enhancer and Puerarin Tablet (1.Key Laboratory of Modern Preparation of TCM , Ministry of Education, Nanchang, 330004, China;2.Department of Pharmacy,The People's Hospital of Ganzhou, Ganzhou, 341000)
Analysis of Quality Markers Related to Expelling Phlegm and Arresting Coughing of Trichosanthis Fructus Based Pharmacokinetics and Multivariate Statistical Methods
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