Progress in Research on Absorption of Breviscapine and Strategies for Absorption-Enhancement
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Progress in Research on Absorption of Breviscapine and Strategies for Absorption-Enhancement
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 9, Pages: 219-222(2010)
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Published:2010
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WU Jun-zhu, YAN Ya, GAO Peng-fei. Progress in Research on Absorption of Breviscapine and Strategies for Absorption-Enhancement[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(9): 219-222.
DOI:
WU Jun-zhu, YAN Ya, GAO Peng-fei. Progress in Research on Absorption of Breviscapine and Strategies for Absorption-Enhancement[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(9): 219-222.DOI:
Progress in Research on Absorption of Breviscapine and Strategies for Absorption-Enhancement
Objective: To review advances of absorption pharmacokinetics study of scutellarin and strategies for its absorption enhancement. Method : According to the findings made in the related researches
absorption characteristic of scutellarin by peroral
nasal
pulmonary and transdermal delivery and the strategies for its absorption enhancement are summarized. Result : The low oral bioavailability could be attributed to its poor solubility both in water and in oil
MRP2-efflux function and metabolism in the gastrointestinal tract. Conclusion : The oral absorption of scutellarin could be enhanced by improving its solubility either in water or in oil
inhibiting drug efflux and developing micro and nano drug delivery systems. In addition
nasal
pulmonary and transdermal drug delivery might be considered as non-invasive systemic delivery of scutellarin.
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In Vitro and in Vivo Evaluation ofScutellarin-phospholipid Complex Nanoemulsion and Analysis of Its Activity in Ameliorating LPS-induced Vascular Endothelial Injury
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CHEN Xiao-xin
XIAO Ri-ping
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LIAO Xiao-ying
LI Geng
LONG Chao-feng
GAO Jie
LI Shiyang
Related Institution
Wuya College of Innovation,Shenyang Pharmaceutical University
Suzhou Youseen New Drug Research&Development Co. Ltd.
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School of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine
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