Hydroxynaphthoquinone Compounds From  and Their Inhibitory Activities of Phosphodiesterase4

ZHAO Hai-qing; LIU Jun-feng; LIU Ke

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Hydroxynaphthoquinone Compounds From and Their Inhibitory Activities of Phosphodiesterase4

更新时间：2024-01-04

- Hydroxynaphthoquinone Compounds From and Their Inhibitory Activities of Phosphodiesterase4
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 10, Pages: 96-99(2010)
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- Published：2010
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ZHAO Hai-qing, LIU Jun-feng, LIU Ke. Hydroxynaphthoquinone Compounds From and Their Inhibitory Activities of Phosphodiesterase4[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 96-99.
DOI：

ZHAO Hai-qing, LIU Jun-feng, LIU Ke. Hydroxynaphthoquinone Compounds From and Their Inhibitory Activities of Phosphodiesterase4[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 96-99. DOI：

摘要

目的 :研究新疆紫草羟基萘醌的主要成分及对PDE4酶的抑制作用。方法 :用硅胶柱层析、制备HPLC 和制备TLC等方法分离纯化新疆紫草中羟基萘醌化合物

通过理化性质和光谱数据进行结构鉴定。HPLC方法测定主要羟基萘醌类化合物对PDE4酶的抑制活性。结果 :分离鉴定了7个化合物

分别为去氧阿卡宁(1)、阿卡宁(2)、乙酰阿卡宁(3)、β

β'-二甲基丙烯酰阿卡宁(4)、α-甲基丁酰阿卡宁(5)、异丁酰阿卡宁(6)和β-乙酰氧基异戊酰阿卡宁(7)。结论 :化合物2

6为首次从新疆紫草中分离得到。首次评价了新疆紫草羟基萘醌类成分对PDE4酶的抑制作用。

Abstract

Objective: To investigate the Hydroxynaphthoquinone of Arnebia euchroma(Royle) Johnst and their inhibitory activities on phosphodiesterase 4. Method: Hydroxynaphthoquinones were isolated and purified by chromatographic methods .Their chemical structures were elucidated on the basis of physicochemical properties and spectral data and their inhibitory activity on phosphodiesterase 4 were detected by HPLC. Result: 7 Hydroxynaphthoquinones were isolated and identified as: deoxyalkannin 1

alkannin 2

acetylalkannin 3

β-dimethylacrylalkannin 4

α-methybutyrylalkannin 5

isobutyrylalkannin 6

β-acetoxyisovalerylalkannin 7. Conclusion: Compounds 2

6 were isolated fromArnebia euchromafirst time.Their inhibitory activities on phosphodiester -ase 4 were evaluated by HPLC method for first time.

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