Determination of 8-epideoxyloganic Acid in Duyiwei Soft Capsules by HPLC

SANG Yu-li; HAO Yan-jun; CHEN Chen; XU Jia-tong

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Determination of 8-epideoxyloganic Acid in Duyiwei Soft Capsules by HPLC

更新时间：2024-01-04

- Determination of 8-epideoxyloganic Acid in Duyiwei Soft Capsules by HPLC
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 13, Pages: 107-108(2010)
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- Published：2010
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SANG Yu-li, HAO Yan-jun, CHEN Chen, et al. Determination of 8-epideoxyloganic Acid in Duyiwei Soft Capsules by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 107-108.
DOI：

SANG Yu-li, HAO Yan-jun, CHEN Chen, et al. Determination of 8-epideoxyloganic Acid in Duyiwei Soft Capsules by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 107-108. DOI：

摘要

目的 :建立独一味软胶囊中8-epideoxyloganic acid的含量测定方法。方法 :采用高效液相色谱法。色谱柱:迪马C18(4.6 mm×250 mm

5 μm)

柱温40 ℃

流动相甲醇-0.025 mol ·L-1磷酸水(50 ∶50)

流速1.0 mL · min-1

检测波长238 nm。结果 :8-epideoxyloganic acid进样量在1.979 2~9.896 μg线性关系良好

回收率均在95.20%~100.00%

RSD均小于5%。结论 :此方法准确可靠

重复性好

结果稳定

可作为独一味软胶囊及其他独一味制剂中环烯醚萜成分含量测定的方法。

Abstract

Objective: To set up a method for the determination of 8-epideoxyloganic acid in Duyiwei soft capsule. Method: The quantitative analysis was performed on Diamond C18(4.6 mm×250 mm

59 μm)column and a mixture of methonal-0.025 mol ·L-1 phosphate solution (50 ∶50) was used as the mobile phrase at a flow rate of 1.0 mL·min-1. The column temperature was at 40 ℃ and the detective wavelength was at 238 nm. Result: The linear range was 1.979 2~9.896 μg for 8-epideoxyloganic acid. The average recovery was 96.84% with RSD 2.07%. Conclusion: The method was accurate

reproducible

stable

and can be used as a quantitative standard for determination of iridoid glycosides in Duyiwei soft capsule.

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ZHANG Xuejing

GUO Yunlong

CAI Guangzhi

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Xiao-xia XUE

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Related Institution

School of Pharmaceutical Sciences， Changchun University of Chinese Medicine

Jilin Ginseng Academy，Changchun University of Chinese Medicine

Sunflower Pharmaceutical Group（Xiangyang） Longzhong Co. Ltd.，Xiangyang

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences，Beijng

Shanxi University of Chinese Medicine

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