Effects of Xinjia Xiayuxue Tang on Bone Morphogenetic Protein 7 and Transforming Growth Factor 1 in Kidney of Diabetic Rats
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Effects of Xinjia Xiayuxue Tang on Bone Morphogenetic Protein 7 and Transforming Growth Factor 1 in Kidney of Diabetic Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 11, Pages: 135-138(2010)
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Published:2010
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DU Yue-guang, YANG Ming-hua, CHAI Ke-fu, et al. Effects of Xinjia Xiayuxue Tang on Bone Morphogenetic Protein 7 and Transforming Growth Factor 1 in Kidney of Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 135-138.
DOI:
DU Yue-guang, YANG Ming-hua, CHAI Ke-fu, et al. Effects of Xinjia Xiayuxue Tang on Bone Morphogenetic Protein 7 and Transforming Growth Factor 1 in Kidney of Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 135-138.DOI:
Effects of Xinjia Xiayuxue Tang on Bone Morphogenetic Protein 7 and Transforming Growth Factor 1 in Kidney of Diabetic Rats
Objective: To explore the protective mechanism of Xinjia Xiayuxue Tang on kidneys in diabetic rats by investigating the effect of Xinjia Xiayuxue Tang on bone morphogenetic protein 7(BMP7) and transforming growth factor β1(TGFβ1 )in kidneys of diabetic rats. Method: SD rats were divided into control group and diabetes model group. The diabetes model was established by injection of alloxan through vena caudalis
and then were randomly divided into diabetes model(DM) group and Xinjia Xiayuxue Tang -treated group. After 12 weeks
The fasting blood glucose (FBG)
serum creatinine (Scr)
urine protein (Upro) were checked with biochemical methods. The morphological changes of renal tissue were examined under microscopy on sections stained with PAS. The mRNA expression of BMP7
TGFβ1 and plasminogen activator inhibitor 1(PAI1)were tested by RT-PCR. Result: Compared with DM model group
in Xinjia Xiayuxue Tang -treated group
FBG
Scr and Upro were markedly decreased (P<0.01);renal damage were significantly reduced
the expression of TGFβ1 and PAI1 mRNA were significantly reduced
BMP7 mRNA expression was greatly increased. Conclusion: Xinjia Xiayuxue Tang exerted protective effect on diabetic nephropathy probably via elevation of BMP7 and reduction of TGFβ1
Effects of Xinjia Xiayuxue Tang on Bone Morphogenetic Protein 7 and Transforming Growth Factor β1 in Kidney of Diabetic Rats
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Related Author
DU Yue-guang1
YANG Ming-hua2
CHAI Ke-fu1
JIN Guo-ying1
XIE Jiarun
LIN Haoyu
CHEN Xi
SUN Jia
Related Institution
Basic Medical College,Zhejiang Chinese Medical University
Zhejiang Provincial Research Institute of Chinese Materia Medica
School of Traditional Chinese Medicine,Southern Medical University
Zhujiang Hospital of Southern Medical University
Beijing Hospital of Traditional Chinese Medicine(TCM) Affiliated to Capital Medical University