Shuganyishen’s Effect on Transplantable Endometrial Carcinoma in Mice and its Mechanism
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Shuganyishen’s Effect on Transplantable Endometrial Carcinoma in Mice and its Mechanism
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 10, Pages: 175-178(2010)
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Published:2010
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FAN Xiu-hua, LU Wen-ping, LI Xiao, et al. Shuganyishen’s Effect on Transplantable Endometrial Carcinoma in Mice and its Mechanism[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 175-178.
DOI:
FAN Xiu-hua, LU Wen-ping, LI Xiao, et al. Shuganyishen’s Effect on Transplantable Endometrial Carcinoma in Mice and its Mechanism[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(10): 175-178.DOI:
Shuganyishen’s Effect on Transplantable Endometrial Carcinoma in Mice and its Mechanism
study on the inhibitory effect of shuganyishen on Ishikawa cells on mouse model. Method: Immunohistochemical method was used to detect the expressions of ERα
ERβ and PR in the transplantable endometrial carcinoma of mice in control group
shuganyishen group
cisplatin group and shuganyishen-cisplatin group. Result: ERα protein expressed highest in control group
and in cisplatin group
shuganyishen group and shuganyishen-cisplatin group in order. ERβ protein expressed highest in shuganyishen group
and in shuganyishen-cisplatin group
control group and cisplatin group in order. PR protein expressed highest in shuganyishen-cisplatin group
and in shuganyishen group
cisplatin group and control group in order. Conclusion: Shuganyishen has a certain effect on inhibiting endometrial carcinoma. Furthermore
shuganyishen combined with conventional chemotherapy is good to inhibit tumor and ERα and improve the expression of PR
without affecting ERβ. So the combined prescription can solve the problem of estrogen inhibition caused by using chemotherapy alone.
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