Comparing Dissolution of Effective Ingredients from Micro-powder and Crude Powder of
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Comparing Dissolution of Effective Ingredients from Micro-powder and Crude Powder of
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 14, Pages: 64-67(2010)
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Published:2010
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NIU Yao-hu, WANG Lan-xia, LI Shi-bo, et al. Comparing Dissolution of Effective Ingredients from Micro-powder and Crude Powder of [J]. Chinese journal of experimental traditional medical formulae, 2010, 16(14): 64-67.
DOI:
NIU Yao-hu, WANG Lan-xia, LI Shi-bo, et al. Comparing Dissolution of Effective Ingredients from Micro-powder and Crude Powder of [J]. Chinese journal of experimental traditional medical formulae, 2010, 16(14): 64-67.DOI:
Comparing Dissolution of Effective Ingredients from Micro-powder and Crude Powder of
用反相HPLC测定不同时间点红景天微粉和粗粉中这3种成分从透析袋中的溶出情况。 结果: 红景天微粉中红景天苷和儿茶素溶出的速度及程度均较粗粉有明显提高(15~45 min
P<0. 05
45~60 min
P<0. 01)
但是没食子酸在2种粉体中的溶出差异并不明显。 结论: 红景天制成微粉后
能有效改善大部分有效成分的溶出速率和溶出效率
对药物作用有一定的促进作用
但进一步的评价有待于更多的试验数据支持。
Abstract
Objective: To investigate the experimental proof for the application of super fine crushing technique (SFCT) to the traditional Chinese medicinal herb and develop new methods to evaluate the effect of SFCT on drug. Method: The dissolution of Rhodiola rosea prepared by different techniques was investigated by dialysis determining gallic acid
salidroside and catechin as the test marker. These markers were determined at different time by RP-HPLC. Result: The speed and degree of dissolution of salidroside and catechin were improved in micro-powder than those in crude powder after a certain time (15- 45 min
P<0.05
45- 60 min
P<0.01)
but the difference of the gallic acid dissolution in the two kinds of powder were not obvious. Conclusion: Both the dissolution of effect component in R.rosea and the effect of Rhodiola rosea can be improved by SFCT.