Effect of  L. on Immunity Hepatic Fibrosis in Rats (Ⅰ)

LI Ping; YANG Zheng-teng; PENG Bai-cheng; ZHEN Dan-dan

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Effect of L. on Immunity Hepatic Fibrosis in Rats (Ⅰ)

更新时间：2024-09-23

- Effect of L. on Immunity Hepatic Fibrosis in Rats (Ⅰ)
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 6, Pages: 171-173(2010)
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- Published：2010
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LI Ping, YANG Zheng-teng, PENG Bai-cheng, et al. Effect of L. on Immunity Hepatic Fibrosis in Rats (Ⅰ)[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 171-173.
DOI：

LI Ping, YANG Zheng-teng, PENG Bai-cheng, et al. Effect of L. on Immunity Hepatic Fibrosis in Rats (Ⅰ)[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 171-173. DOI：

摘要

目的 :探讨余甘子对猪血清所致大鼠免疫性肝纤维化的影响。方法 :采用大鼠ip猪血清

造成大鼠肝纤维化

ig余甘子提取物

采用放射免疫分析法测定其血清透明质酸(HA)、Ⅲ型前胶原氨基端肽(PⅢNP)、层黏连蛋白(LN)、超氧化物歧化酶(SOD)、丙二醛(MDA)、L-羟脯氨酸(Hyp)的含量

检测细胞因子肿瘤坏死因子-α(TNF-α)、软化性因子(TGF-β)

探讨余甘子抗免疫性肝纤维化的作用机制。结果: 余甘子提取物能减少TNF-α

TGF-β的含量

减少HA

PⅢNP

MDA

Hyp含量

升高SOD活性

其作用呈剂量依赖性。结论: 余甘子对猪血清致大鼠肝纤维化模型具有较好的抗肝纤维化作用。

Abstract

Objective: To study the effect of Phyllanthus emblica L. on liver fibrosis indexes in liver fibrosis rats caused by porcine serum. Method: The rats were injected with porcine serum though intraperitonea to lead to the liver fibrosis

and the rats were given the extraction of P. emblica. With the methods of radioimmunity assay

the HA

PⅢNP

SOD

MDA and Hyp were tested at the same time

the TNF-α

TGF-β were also tested. By doing so

the action mechanisms of P. emblica was explored. Result: The extraction of P emblica was able to reduce the content of TNF-α

TGF-β

PⅢNP

MDA and Hyp.It also increased the activity of SOD. The actions were in a dose-dependent manner. Conclusion: P. emblica have a good role in anti-liver fibrosis induced by porcine serum in rats.

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Related Author

ZHEN Dan-dan3

LI Ping1

YANG Zheng-teng2

PENG Bai-cheng2

HUANG Jian

PENG Bai-cheng

LI Pin

MU Yong-ping

Related Institution

Guangxi College of TCM,Nanning 530001,China: 2.Nanning Hospital of TCM

The First Hospital,Guangxi College of TCM

广西中医学院第一附属医院

College of Traditional Chinese Medicine,Southern Medical University

Shanghai University of TCM

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