Application of Biotechnology for Decreasing Toxicity and Increasing Efficacy of

TANG Yuan-yuan; LIU Qian; ZHANG Jing-hong

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Application of Biotechnology for Decreasing Toxicity and Increasing Efficacy of

更新时间：2024-01-04

- Application of Biotechnology for Decreasing Toxicity and Increasing Efficacy of
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 9, Pages: 214-218(2010)
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- Published：2010
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TANG Yuan-yuan, LIU Qian, ZHANG Jing-hong. Application of Biotechnology for Decreasing Toxicity and Increasing Efficacy of [J]. Chinese journal of experimental traditional medical formulae, 2010, 16(9): 214-218.
DOI：

TANG Yuan-yuan, LIU Qian, ZHANG Jing-hong. Application of Biotechnology for Decreasing Toxicity and Increasing Efficacy of [J]. Chinese journal of experimental traditional medical formulae, 2010, 16(9): 214-218. DOI：

摘要

目的 :阐述生物技术在雷公藤Tripterygium wilfordii hook减毒增效研究中的应用概况。方法 :总结国内外相关文献

从生物靶向给药、酶和细胞对单体进行修饰、内生菌中分离有效成分以及整体发酵等方面归纳生物技术在雷公藤减毒增效研究中的应用。结果 :通过将药物靶向运输到病变部位、对单体有效成分进行结构修饰、整体转化雷公藤以及从内生菌中分离有效成分等手段

生物技术能在单体有效成分和雷公藤整体水平上对雷公藤进行减毒增效。结论 :采用模式菌和重组基因工程菌转化雷公藤各种减毒增效成分

同时积极筛选生物脱毒相关基因或毒理作用的最佳靶点并合成其抑制剂得到减毒成分将是雷公藤减毒增效研究的一个重要方向。

Abstract

Objective: To outline the application of biotechnology in decreasing the toxicity and increasing the efficacy of Tripterygium. Method : The related literatures

including articles concerning biologically targeting drug delivery

modifying a ingredient by enzymes or cells

isolating effective components from endophytes and the overall fermentation of Tripterygium. Result : By delivering drugs to the lesion site

modifying an ingredient

isolating effective components from endophytes and overall fermenting of Tripterygium

the biotechnology could decrease the toxicity and increase the efficacy of Tripterygium at both monomer and overall level. Conclusion : The application of biotechnology

including biotransforming effective ingredients of Tripterygium by type and genetic engineering bacteria

screening the best targets from the related genes of biotical detoxification and toxicological effects

and synthesizing their inhibitors to get the efficacy components

will be an important direction in the research of Tripterygium.

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Related Author

Yi-jie HUANG

Lin-lin DONG

Guang-fei WEI

Xiao-hui ZHANG

Chun-yan LI

Lin-hao CHEN

Ya-lin YANG

Wen-qing YIN

Related Institution

Dali University，Dali

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Institute of Medical Information， Chinese Academy of Medical Science &Peking Union Medical College

School of Chemistry and Chemical Engineering, Lingnan Normal University

School of Chinese Materia Medica, Beijing University of Chinese Medicine

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