Objective: Experimental observation on effectiveness of modified Banxia Baizhu Tianma Tang for treatment of hyperlipidemia in order to provide pharmacodynamic basis for clinical treatment. Method: Rats were given high fat diet for 4 weeks

resulting in model of hyperlipidemia

meanwhile three doses of the modified Banxia Baizhu Tianma Tang was given. Changes in body weight

TG

CHOL

LDL

HDL

apoA1

apoB

SOD

MDA were observed during the process. Result: Body weight of high-dose group was increased compared with the model group at the same period. Serum triglyceride in three dosage groups was significantly reduced

serum CHOL

LDL levels in high-dose group were significantly reduced compared with the model group (P<0.05). Serum HDL levels in three dosage groups were increased to some degrees compared with model group

however

without significance. The levels of serum apo A1 had no significant changes in three dosage groups

while apo B levels in the three dosage groups and in the positive control group of steatohepatitis appeared a trend of decrease

the most obvious one was in the high dose group compared with the model group. SOD activity was increased to various degree in three dosage groups while with reduced MDA content compared with model group

the most obvious one was the high dose group. Conclusion: The modified Banxia Baizhu Tianma Tang can clearly improve the parameters related to hyperlipidemia.