Study on Solubility and Stability of Honokiol in Buffer Solution of HBSS
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Study on Solubility and Stability of Honokiol in Buffer Solution of HBSS
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 13, Pages: 90-93(2010)
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Published:2010
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WU An-guo, ZENG Bao, WANG Chun-ling, et al. Study on Solubility and Stability of Honokiol in Buffer Solution of HBSS[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 90-93.
DOI:
WU An-guo, ZENG Bao, WANG Chun-ling, et al. Study on Solubility and Stability of Honokiol in Buffer Solution of HBSS[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 90-93.DOI:
Study on Solubility and Stability of Honokiol in Buffer Solution of HBSS
Objective: To investigate the solubility and stability of honokiol in HBSS
Establish the basis of the drug metabolism research. Method: The concentration of honokiol was determined by RP-HPLC method
pH
temperatures and light were investigated on the solubility and stability of honokiol. Result: The linear calibration curve of Honokiol in methanol in the concentration range of 4-200 μmol·L-1 with a detection limit of 0.2 μmol/L
The equation was calculated to be Y=4 764.5X-10 955(r=0.999)
The precision and stability accorded with the requirements of methodology. The solubility of honokiol is good in HBSS containing 1% methanol and 0.1% Tween -80
the stability of honokiol in HBSS of acidic is more better than HBSS of alkaline
.light on the stability of honokiol has no influence. Conclusion: Tthe solubility and stability of honokiol in HBSS of pH 7.4 is rather ideal
when it reached the dissolution equilibrium it should be storied at -20 ℃.