Objective: To explore the 'hoodwinks nature’ of dampness evil by detecting the expression of TCRVβ subfamilies in peripheral blood mononuclear cell of chronic hepatitis B (CHB) patients with dampness syndrome and healthy people by F-Q PCR technique. Method: Three patients with dampness syndrome and one healthy person were included

Three patients with dampness syndrome were treated by clearing dampness method (modified Huopuxialing decotion).The symptoms

signs and TCRVβ subfamilies expresssion were determined before and after being treated. Result : The liver function of three CHB patients with dampness syndrome recovered to normal levels after treatment

and the symptoms were improved in the same time.The levels of TCRVβ1

TCRVβ6.1

TCRVβ7

TCRVβ8 were increased while the levels of TCRVβ12

TCRVβ14 were decreased after treatment. Conclusion :The expression quantities of TCRVβ subfamilies of CHB patients with dampness syndrome were disordered

and the expression quantities of these subfamilies could be adjusted to a certain extent after clearing dampness treatment

which hinted that the abnormal expression of TCRVβ subfamilies’ might be the cause of decreased immunity of CHB patients with dampness syndrome.