Effect of  Extracts on Lipid Peroxidation of Lipoproteins in Rabbits with Hyperlipidemia

YIN Xue-zhe; XU Hui-xian; JIN Ai-hua; QUAN Ji-shu

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Effect of Extracts on Lipid Peroxidation of Lipoproteins in Rabbits with Hyperlipidemia

更新时间：2024-09-23

- Effect of Extracts on Lipid Peroxidation of Lipoproteins in Rabbits with Hyperlipidemia
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 11, Pages: 132-134(2010)
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- Published：2010
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YIN Xue-zhe, XU Hui-xian, JIN Ai-hua, et al. Effect of Extracts on Lipid Peroxidation of Lipoproteins in Rabbits with Hyperlipidemia[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 132-134.
DOI：

YIN Xue-zhe, XU Hui-xian, JIN Ai-hua, et al. Effect of Extracts on Lipid Peroxidation of Lipoproteins in Rabbits with Hyperlipidemia[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 132-134. DOI：

摘要

目的 :研究草苁蓉提取物(BRE)对实验性高脂血症兔血浆脂蛋白抗脂质过氧化作用的影响。方法: 高脂饲料喂养法建立兔高脂血症模型

连续给药8周后分离血浆脂蛋白

观察各血浆脂蛋白过氧化脂质(LPO)含量及低密度脂蛋白(LDL)氧化易感性的变化。结果: 饲喂BRE后高脂血症兔血浆总胆固醇(TC)、极低密度脂蛋白胆固醇(VLDL-CH)和低密度脂蛋白胆固醇(LDL-CH)水平明显降低;血浆总LPO和脂蛋白LPO含量明显减少;在体外进行氧化修饰时

LDL氧化延滞时间明显延长。结论: BRE可降低高脂血症兔血脂水平和血浆脂蛋白脂质过氧化程度

增强LDL抗氧化修饰能力

因此能够起到防治动脉粥样硬化症的积极作用。

Abstract

Objective: To study the inhibitory effect of Boschniakia rossica extracts (BRE) on lipid peroxidation of plasma lipoproteins in rabbits with hyperlipidemia. Method: The hyperlipidemic model were established by feeding rabbits with high-fat diet. After 8 weeks of treatment

plasma lipoproteins were isolated

and then lipid peroxide (LPO) and susceptibility of low density lipoprotein (LDL) to oxidation was investigated. Result: After the administration with BRE

the levels of plasma total cholesterol (TC)

very low density lipoprotein cholesterol (VLDL-CH) and low density lipoprotein cholesterol (LDL-CH) in hyperlipidemic rabbits were significantly reduced; LPO levels of plasma and lipoproteins were significantly decreased; and the lag phage of LDL oxidation curve in vitro was noticeably prolonged. Conclusion: BRE

which can reduce blood lipids

decrease the lipid peroxidizability of lipoproteins and promote resistance to LDL oxidation

may be useful in the prevention and treatment of atherosclerosis.

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Related Author

YIN Xue-zhe1

XU Hui-xian1

JIN Ai-hua2

QUAN Ji-shu2

YANG Lele

LUO Danmei

CHEN Jiao

ZHANG Xiaobo

Related Institution

Hospital of Yanbian University,Yanji

College of Basic Medicine,Yanbian University,Yanji

Chengdu University of TCM

Hospital of Chengdu University of Traditional Chinese Medicine （TCM）

Hospital of Chengdu University of TCM

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