Correspondence between Syndrome of Hyperactivity of Liver-yang and Prescriptions of Lingjiao Jiangya Prescription, Tianma Gouteng Prescription

CHEN Su-hong; LV Gui-yuan; CHEN Ning; CHEN Xiao-lin; LIU Li-jun

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Correspondence between Syndrome of Hyperactivity of Liver-yang and Prescriptions of Lingjiao Jiangya Prescription, Tianma Gouteng Prescription

更新时间：2024-09-23

- Correspondence between Syndrome of Hyperactivity of Liver-yang and Prescriptions of Lingjiao Jiangya Prescription, Tianma Gouteng Prescription
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 11, Pages: 128-131(2010)
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- Published：2010
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CHEN Su-hong, LV Gui-yuan, CHEN Ning, et al. Correspondence between Syndrome of Hyperactivity of Liver-yang and Prescriptions of Lingjiao Jiangya Prescription, Tianma Gouteng Prescription[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 128-131.
DOI：

CHEN Su-hong, LV Gui-yuan, CHEN Ning, et al. Correspondence between Syndrome of Hyperactivity of Liver-yang and Prescriptions of Lingjiao Jiangya Prescription, Tianma Gouteng Prescription[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 128-131. DOI：

摘要

目的 :探索羚角降压方、天麻钩藤方与高血压肝阳上亢证证候的相应性。方法: 采用附子汤+麻黄碱+盐水三因素制备大鼠高血压肝阳上亢证模型。SD大鼠50只

随机分为正常对照组、模型对照组、羚角降压方组、天麻钩藤方组、金匮肾气方组

共5组

每组10只

连续给药28 d。给药后每隔6d测定大鼠面温、抓力、收缩压、舒张压和平均动脉压

每隔14 d观察大鼠性情及毛色变化。结果: 给药14 d后羚角降压方、天麻钩藤方可降低肝阳上亢模型大鼠面部温度和血压;21 d后羚角降压方、天麻钩藤方、金匮肾气方可增大大鼠抓力;28 d后3个复方均可改善毛色

其中羚角降压方、天麻钩藤方可改善躁狂症状。结论: 天麻钩藤方、羚角降压方具有平肝潜阳之功效

能平抑阳亢、滋补阴虚

改善高血压肝阳上亢证之"面部烘热"、"腰膝酸软"、"狂躁易怒"

降低收缩压

具有一定的方-证相应性。

Abstract

Objective: To understand the correspondence between syndrome of hyperactivity of liver-yang and the prescriptions of Lingjiao Jiangya Prescription (LJP) and Tianma Gouteng Prescription (TMGTP). Method: Aconium carmichaeli Debx.

ephedrine and salty water were used to establish the rat model of hypertension with syndrome of hyperactivity of liver-yang. Fifty SD rats were divided into five groups

including normal control

model

LJP

TMGTP and Jinkuishenqi Prescription (JKSQP). The medicines were given for 28 days

facial temperature

grip strength

systolic pressure

diastolic pressure and mean arterial pressure were determined per 7 days

and rat temper and coat color were observed per 14 days. Result: On day14

LJP and TMGTP could decrease the facial temperature and the blood pressure. On day21

all three prescriptions could strengthen rat grip strength. On day28

the prescriptions could ameliorate rat coat color

and LJP and TMGTP could keep rats calm. Conclusion: LJP and TMGTP could restrain hyperactivity of liver-yang

ameliorate yin-deficiency

relieve hypertension

and decrease the systolic pressure. So the correspondence between the prescriptions of LJP and TMGTP and hypertension with syndrome of hyperactivity of liver-yang has been confirmed.

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Related Author

CHEN Su-hong 1

LV Gui-yuan2

CHEN Ning2

CHEN Xiao-lin2

LIU Li-jun2

WANG Tengjian

ZHAO Wanlu

YU Yang

Related Institution

Zhejiang University of Traditional Chinese Medical

Wenzhou Medical College

School of Pharmaceutical Sciences， Zhejiang Chinese Medical University

Guang'anmen Hospital， China Academy of Chinese Medical Sciences

Key Laboratory of Dunhuang Medicine， Ministry of Education

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