Effect of Puwei Pill on Anti-oxidation and Improvement of Gastric Mucosal Blood Flow in Rats with Gastric Ulcer Recurrence

JIA Xin; FENG Yong; GENG Fei; LV Hua; LIU Shu-mei; BAI Jing; QI Ya-juan

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Effect of Puwei Pill on Anti-oxidation and Improvement of Gastric Mucosal Blood Flow in Rats with Gastric Ulcer Recurrence

更新时间：2024-09-23

- Effect of Puwei Pill on Anti-oxidation and Improvement of Gastric Mucosal Blood Flow in Rats with Gastric Ulcer Recurrence
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 5, Pages: 183-185(2010)
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- Published：2010
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JIA Xin, FENG Yong, GENG Fei, et al. Effect of Puwei Pill on Anti-oxidation and Improvement of Gastric Mucosal Blood Flow in Rats with Gastric Ulcer Recurrence[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 183-185.
DOI：

JIA Xin, FENG Yong, GENG Fei, et al. Effect of Puwei Pill on Anti-oxidation and Improvement of Gastric Mucosal Blood Flow in Rats with Gastric Ulcer Recurrence[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 183-185. DOI：

摘要

目的: 研究普胃丸(PWP)对复发胃溃疡大鼠抗氧化及改善胃黏膜血流的作用。方法: 采用白细胞介素1β(IL-1β)制备大鼠胃溃疡复发模型

观察连续ig PWP 90 d胃组织病理学变化

测定血浆中超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)、内皮素-1(ET-1)及胃黏膜组织ET-1A的表达。结果: PWP能明显降低溃疡复发率

增加血浆SOD、NO活性

减少MDA、ET-1含量

显著抑制复发胃溃疡胃黏膜组织中ET-1A的表达。结论: PWP可抑制胃溃疡复发

其机制与增强机体抗氧化及改善黏膜血流量有关。

Abstract

Objective: To study the effect of Puwei Pill(PWP) on the anti-oxidation and improvement of the gastric mucosal blood flow in the rats with gastric ulcer recurrence. Method: The gastric ulcer recurrence model was developed by intraperitoneal injection with interleukin-1β(IL-1β). Then the pathohistological structure in the recurred gastric ulcer

treated by PWP(ig

90 d)

was observed. The superoxide dismutase(SOD)

nitric oxide(NO)

malondialdehyde(MDA) and endothelin-1 (ET-1) in the plasma and ET-1A expressed in the gastric mucosa were determined. Result: PWP could significantly resist the recurrence of gastric ulcer

increase the SOD

NO activity and decrease the contents of MDA and ET-1 in plasma. At the same time

PWP could significantly inhibit the ET-1A expression in the gastric mucosa. Conclusion: PWP can prevent the recurrence of the gastric ulcer

which mechanism is probably related to the increase of anti-oxidation capacity and improvement of mucosal blood flow.

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Related Author

JIA Xin

FENG Yong

GENG Fei

LV Hua

LIU Shu-mei

BAI Jing

QI Ya-juan

JIANG Yan

Related Institution

The Department of Pharmacology,North China Coal Medical College

Hebei United University,Jitang College

Hebei United University,Department of Pharmacology

Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-yao

Henan University of Chinese Medicine

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