Effects of Shenchang Injection on Platelet Activation and Thrombosis in MCAO Rats
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Effects of Shenchang Injection on Platelet Activation and Thrombosis in MCAO Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 5, Pages: 175-177(2010)
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Published:2010
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LI Ling, FANG Yong-qi, ZOU Yan-yan, et al. Effects of Shenchang Injection on Platelet Activation and Thrombosis in MCAO Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 175-177.
DOI:
LI Ling, FANG Yong-qi, ZOU Yan-yan, et al. Effects of Shenchang Injection on Platelet Activation and Thrombosis in MCAO Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 175-177.DOI:
Effects of Shenchang Injection on Platelet Activation and Thrombosis in MCAO Rats
Objective: To observe effects of Shenchang Injection on platelet activation and thrombosis in MCAO rats. Method: The cerebral injury model induced by ischemia/reperfusion was made in rat by MCAO. Shenchang injection was given by iv for 7 times
then CD62p、CD63 were measured by flow-cytometry. Thrombosis and clotting time were observed. Result: Shenchang injection could decrease expression of CD62p and CD63 in blood
decline thrombosis in kidney vein
delay clotting time in MCAO rats. Conclusion: Shenchang injection is effect for antiplatelet activities and postponement of thrombosis by extending blood clotting. These are likely the pharmacological basis of the injection for treating stroke.