Experimental Study of Suoquan Capsule on Renin-Angiotensin-Aldosterone System in Rats with Diuresis and Deficiency of Kidney

LI Shu-wen; WU Qing-he; HUANG Ping; CAO Hong-ying

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Experimental Study of Suoquan Capsule on Renin-Angiotensin-Aldosterone System in Rats with Diuresis and Deficiency of Kidney

更新时间：2024-09-23

- Experimental Study of Suoquan Capsule on Renin-Angiotensin-Aldosterone System in Rats with Diuresis and Deficiency of Kidney
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 11, Pages: 108-110(2010)
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- Published：2010
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LI Shu-wen, WU Qing-he, HUANG Ping, et al. Experimental Study of Suoquan Capsule on Renin-Angiotensin-Aldosterone System in Rats with Diuresis and Deficiency of Kidney[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 108-110.
DOI：

LI Shu-wen, WU Qing-he, HUANG Ping, et al. Experimental Study of Suoquan Capsule on Renin-Angiotensin-Aldosterone System in Rats with Diuresis and Deficiency of Kidney[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 108-110. DOI：

摘要

目的 :通过研究缩泉丸对肾素-血管紧张素-醛固酮系统(RAAS)的调节作用

阐明其补肾缩尿的机制。方法 :采用腺嘌呤造成肾虚多尿大鼠模型

利用酶联免疫分析法分别检测正常对照组、模型对照组、缩泉丸组、金锁固精丸组血中血管紧张素转化酶(ACE)、肾素(PRA)、血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)的含量。结果 :与模型对照组比较

缩泉丸可显著提高肾虚多尿大鼠血中ACE

PRA

AngⅡ

ALD含量。结论 :缩泉丸可通过调节RAAS的功能发挥调节人体水液代谢的作用

本试验研究结果从内分泌系统调节的角度阐明了缩泉丸补肾缩尿的作用机制。

Abstract

Objective : To expound the mechanism of nourishing kidney and reducing urine by investigating the regulative action for renin-angiotensin-aldosterone system (RAAS) by Suoquan Capsule. Method: The rat model of kidney deficiency and diuresis was established by adenine. The levels of ACE

PRA

AngⅡ and ALD in blood were determined for model group

Suoquan Capsule group

Jinsuo Gujin Wan group and control group with ELISA technology. Result : Compared with model group

Suoquan Capsule could remarkedly increase the levels of ACE

PRA

AngⅡ and ALD in blood of the rats with kidney deficiency and diuresis. Conclusion : Suoquan Capsule can regulate water metabolism by coordinating the function of RAAS.The mechanism of nourishing the kidney and reducing urine by Souquan Capsule appears to be related with endocrinium system.

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Experimental Study of Suoquan Capsule on Renin-Angiotensin-Aldosterone System in Rats with Diuresis and Deficiency of Kidney

Related Author

LI Shu-wen1

WU Qing-he2

HUANG Ping2

CAO Hong-ying2

Related Institution

Jiangxi College of Traditional Chinese Medicine

College of Traditional Chinese Medicine,Guangzhou University of Chinese Medicine

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