Effect of Formula of Benefiting Qi and Promoting Blood Circulation and Detoxication on Endothelial Function in Younger Spontaneously Hypertensive Rats
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Effect of Formula of Benefiting Qi and Promoting Blood Circulation and Detoxication on Endothelial Function in Younger Spontaneously Hypertensive Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 8, Pages: 154-156(2010)
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Published:2010
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YUE Gui-hua, ZHUO Shao-yuan. Effect of Formula of Benefiting Qi and Promoting Blood Circulation and Detoxication on Endothelial Function in Younger Spontaneously Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 154-156.
DOI:
YUE Gui-hua, ZHUO Shao-yuan. Effect of Formula of Benefiting Qi and Promoting Blood Circulation and Detoxication on Endothelial Function in Younger Spontaneously Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 154-156.DOI:
Effect of Formula of Benefiting Qi and Promoting Blood Circulation and Detoxication on Endothelial Function in Younger Spontaneously Hypertensive Rats
Objective: To study the influence of the formula of benefiting Qi and promoting blood circulation and detoxication on juvenile spontaneously hypertensive rats(SHR)’ endothelium function
and further investigate the prevention mechanism of HBP by the formula. Method: 16 6ws-old male SHR rats were randomly divided into two groups
including the model group and the formula group. After 6 weeks
the changes in blood pressure before and after treatment were detected separately. Besides
the change of serum von Wilebrand factore(vWF) and ET-1 concentration were tested by enzyme linked immunosorbent assay
the content of serum NO was tested by nitrous reductase chromatometry
the SOD was tested by xathine and xanthylic oxidase reaction system
and the MDA was tested by thiobarbital chromatometry. Meanwhile 8 same age WKY rats were used as the blank comparison. Results : In the juvenile plasma
vWF and MDA were significantly (P<0.05) increased
NO and SOD were significantly (P<0.05) decreased. After treatment with the formula of benefiting Qi and promoting blood circulation and detoxication
not only vWF and MDA were significantly (P<0.05) decreased
but also NO and SOD were significantly (P<0.05) increased in the SHP plasma. Conclusion : The insufficiency of endothelium in SHR exists in juvenile stage. The early application with the formula of benefiting Qi and promoting blood circulation and detoxication can improve vascular endothelial function in juvenile SHR.