Effect of VEGF-VEGFR Pathway on EPCs Function Induced by Xuefu Zhuyu Tang
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Effect of VEGF-VEGFR Pathway on EPCs Function Induced by Xuefu Zhuyu Tang
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 11, Pages: 104-107(2010)
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Published:2010
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GAO Dong, WU Li-ya, JIAO Yu-huan, et al. Effect of VEGF-VEGFR Pathway on EPCs Function Induced by Xuefu Zhuyu Tang[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 104-107.
DOI:
GAO Dong, WU Li-ya, JIAO Yu-huan, et al. Effect of VEGF-VEGFR Pathway on EPCs Function Induced by Xuefu Zhuyu Tang[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 104-107.DOI:
Effect of VEGF-VEGFR Pathway on EPCs Function Induced by Xuefu Zhuyu Tang
Objective: To observe the effect of VEGF-VEGFR pathway on EPCs function induced by Xuefu Zhuyu Tang. Method: After induced by serial concentrations of Xuefu Zhuyu Decoction-contained serum (XZDCS) and blank serum
EPCs proliferation
migration
adhension ability and VEGF
VEGFR expression were detected by MTT
Boyden chamber
adhension test and RT-PCR respectively. Result: Compared to the control group
10% XZDCS could elevate the cell regeneration and adhension ability. The EPCs migration ability was inhibited by 5% XZDCS and improved by 10%
15% XZDCS. The higher two concentrations could up-regulate VEGF and VEGFR transcription significantly. Conclusion: Xuefu Zhuyu Tang could induce EPCs into angiogenesis by up regulating VEGF-VEGFR pathway to promote its proliferation