Inhibitory Effects and Mechanism of Bornel on Arterial Thrombosis Induced by FeCl in Rat

YANG Lei; LI Wei-rong; MI Sui-qing; WANG Ning-sheng

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Inhibitory Effects and Mechanism of Bornel on Arterial Thrombosis Induced by FeCl in Rat

更新时间：2024-09-23

- Inhibitory Effects and Mechanism of Bornel on Arterial Thrombosis Induced by FeCl in Rat
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 6, Pages: 164-167(2010)
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- Published：2010
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YANG Lei, LI Wei-rong, MI Sui-qing, et al. Inhibitory Effects and Mechanism of Bornel on Arterial Thrombosis Induced by FeCl in Rat[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 164-167.
DOI：

YANG Lei, LI Wei-rong, MI Sui-qing, et al. Inhibitory Effects and Mechanism of Bornel on Arterial Thrombosis Induced by FeCl in Rat[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(6): 164-167. DOI：

摘要

目的 :探讨冰片的抗血栓作用。方法 :用血栓形成实验、血小板聚集实验及血小板内钙离子浓度的测定

考察冰片对血栓形成、血小板5-羟色胺(5-HT)含量、血小板聚集率及血小板内游离钙离子浓度 i的影响。结果 : ig 冰片粟米油溶液140 mg·kg-1

7次能抑制三氯化铁诱导的大鼠动脉血栓形成(P<0.05)

升高血小板内5-HT含量(P<0.05)

抑制5-HT诱导的血小板聚集作用(P<0.05);在有无细胞外钙存在时

冰片血清均能够明显抑制5-HT诱导的血小板胞内 i升高。结论 :冰片具有抗血栓作用

其机制可能与抑制血小板5HT释放和血小板聚集

抑制血小板胞浆 i升高有关。

Abstract

Objective: To study on the antithrombotic effect of bornel. Method : Thrombosis test

platelets aggregation

and determination platelet i were carried out to investigate the effects of borneol on the following indexes:weight of thrombus

the concentration of serotonin in platelets

platelet aggregation rate

and intracellular free calcium concentration in platelets. Result : Ig 140 mg ·kg-1 borneol daily for 7 days inhibited arterial thrombosis induced by FeCI3

increased the concentration of serotonin in platelets

and inhibited the platelet aggregation induced by 5-HT(P<0.05);with or without the presence of extracellular Ca2+

bornel inhibited the increased i induced by 5-HT. Conclusion : Borneol has anti-thrombosis

and its mechanism may be related to inhibitory effects for the release of platelet 5-HT

for platelet aggregation and for the increase of platelet i.

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Related Author

YANG Lei

LI Wei-rong

MI Sui-qing

WANG Ning-sheng

YU Meishuang

DAI Guoliang

HANG Huaxi

YE Yu

Related Institution

Institute of Clinical Pharmacology,Guangzhou University of Chinese Medicine

Affiliated Hospital of Nanjing University of Chinese Medicine

College of Pharmacy, Chengdu University of Traditional Chinese Medicine(TCM)

Teaching Hospital of Chengdu University of TCM

Henan University of Chinese Medicine

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