Objective: To observe the therapeutic effect of Sijunzitang with chemotherapy in treating gastrointestinal cancer multidrug resistance gene-positive patients. Method: By immunohistochemical methods in our hospital 117 cases of gastrointestinal cancer pathology specimens for detection of multidrug resistance gene

and multidrug resistance gene in which 55 patients were positive for clinical studies

treatment group 28 cases

using Sijunzitang combined with chemotherapy for treatment; the control group 27 cases

only with chemotherapy. Result: Toxic side-effects in patients treated by Sijunzitang combined with chemotherapy were significantly lower than that in chemotherapy group

the completion of chemotherapy rate was 96.4%. In chemotherapy alone group

due to neutropenia or serious gastrointestinal response and chemotherapy had been suspended for some cases

to completion rate was only 70.4%. The treatment group Ⅰ

Ⅱ

Ⅲ period of 5 years survival were 75.0%

63.6%

22.2%

while the control group were 55.6%

37.5%

10.0%. Conclusion: Sijunzitang with chemotherapy has definite effect for the treatment of gastrointestinal tract cancer multidrug resistance gene-positive cases.