Effects of Huangjin Capsule on Enhancing Insulin Sensitivity in Type 2 Diabetic-insulin Resistant Rats

CUI Qin-rong; AN Xiao-ping; KANG Xue-dong; YU Chen-zu

您当前的位置：

首页 >

文章列表页 >

Effects of Huangjin Capsule on Enhancing Insulin Sensitivity in Type 2 Diabetic-insulin Resistant Rats

更新时间：2024-09-23

- Effects of Huangjin Capsule on Enhancing Insulin Sensitivity in Type 2 Diabetic-insulin Resistant Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 5, Pages: 150-152(2010)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2010
- 稿件说明：
移动端阅览
CUI Qin-rong, AN Xiao-ping, KANG Xue-dong, et al. Effects of Huangjin Capsule on Enhancing Insulin Sensitivity in Type 2 Diabetic-insulin Resistant Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 150-152.
DOI：

CUI Qin-rong, AN Xiao-ping, KANG Xue-dong, et al. Effects of Huangjin Capsule on Enhancing Insulin Sensitivity in Type 2 Diabetic-insulin Resistant Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(5): 150-152. DOI：

摘要

目的: 探讨黄金胶囊对2型糖尿病(T2DM)大鼠胰岛素抵抗(IR)的影响

并初步探讨其作用机制。方法 :采用给大鼠腹腔一次性注射小剂量链脲佐菌素(STZ)

并加饲高热量饮食(富含脂肪和蔗糖)

制备T2DM伴IR大鼠模型

观察黄金胶囊对糖尿病大鼠体重、血糖、血清胰岛素和胰岛素敏感性指数的影响。结果 : 黄金胶囊能降低T2DM伴IR模型大鼠空腹血糖;黄金胶囊能降低病鼠高胰岛素血症

提高了胰岛素敏感性指数;实验中未发现明显的不良反应。结论 : 黄金胶囊对T2DM伴IR大鼠有降血糖及改善其IR的作用。

Abstract

Objective: To investigate the effects of Huangjin capsule on insulin sensitivity in type 2 diabetic rats with insulin-resistance (IR) and the primary pharmacological mechanism. Method: The model for type 2 diabetic-insulin-resistant rats (T2DIRR) were performed through intraperitonea injection of lower dosage of streptozocin(30 mg/kg) and high caloric diet (abounded with sugar & fat). The effects of Huangjin on weight

blood and/or serum contents of glucose

lipids

insulin and insulin sensitive index(ISI) were observed in the model rats. Result: Huangjin lowered significantly fasting blood glucose (FBG)(P<0.05) and improved impaired glucose tolerance (IgT); and reduced the concentration of insulin in hyperinsulinemia

and potentiated ISI (P<0.01) in T2DIRR. Conclusion: In the experiment with type 2 diabetic-insulin-resistantrats

Huangjin can reduce the level of blood glucose

and improve insulin sensitivity.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effects of Huangjin Capsule on Enhancing Insulin Sensitivity in Type 2 Diabetic-insulin Resistant Rats

Effects of Huangjin Capsule on Insulin Resistance in Type 2 Diabetic Rats

Mechanism of Qingrun Prescription-containing Serum Improving Insulin Resistance in HepG2 Cells via Branched-chain α-keto Acid Dehydrogenase Regulation of Branched-chain Amino Acids （BCAAs）/mTOR Pathway

Dahuang Huanglian Xiexintang and Its Modified Prescription Improve Type 2 Diabetes Mellitus： A Review

Gegen Qinliantang and Its Modified Prescriptions Ameliorate Insulin Resistance in Type 2 Diabetes Mellitus： A Review

Related Author

CUI Qin-rong1

AN Xiao-ping2

KANG Xue-dong2

YU Chen-zu3

CUI Qing-rong

BU Xiangwei

HAO Xiaohui

ZHANG Runyun

Related Institution

Gansu Authority of Chinese Medicine

Affiliated Hospital of Gansu College of Traditional Chinese Medicine

Gansu College of Traditional Chinese Medicine

Guang'anmen Hospital，China Academy of Chinese Medicine Sciences

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine（TCM）

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰