Studies on the Hypoglycemic Activity of Dahuang Zhechong Pill in Mice

YANG Yao-fang; SHEN Xiao-ying; QIAN Wei; QIAN Qing-qing; JI Min-chun

您当前的位置：

首页 >

文章列表页 >

Studies on the Hypoglycemic Activity of Dahuang Zhechong Pill in Mice

更新时间：2024-09-23

- Studies on the Hypoglycemic Activity of Dahuang Zhechong Pill in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 2, Pages: 104-106(2010)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2010
- 稿件说明：
移动端阅览
YANG Yao-fang, SHEN Xiao-ying, QIAN Wei, et al. Studies on the Hypoglycemic Activity of Dahuang Zhechong Pill in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(2): 104-106.
DOI：

YANG Yao-fang, SHEN Xiao-ying, QIAN Wei, et al. Studies on the Hypoglycemic Activity of Dahuang Zhechong Pill in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(2): 104-106. DOI：

摘要

目的: 研究大黄虫丸对四氧嘧啶所致糖尿病小鼠的降血糖作用。方法: 腹腔注射四氧嘧啶90 mg·kg-1建立小鼠糖尿病动物模型

检测大黄虫丸对实验动物血糖、糖化血红蛋白及血脂的含量。造模前后称体重

解剖分离心、肝、脾、肺、肾、胸腺各脏器称重

计算脏器系数。结果: 四氧嘧啶(90 mg·kg-1)ip小鼠

随着糖尿病模型的形成

小鼠的血糖升高

糖化血红蛋白的含量升高

体重下降及脾脏、胸腺重量减轻。大黄虫丸ig能降低四氧嘧啶糖尿病小鼠的血糖、糖化血红蛋白的水平

能升高高密度脂蛋白

能改善四氧嘧啶糖尿病小鼠的体重下降

增加脾脏及胸腺免疫器官重量。结论: 大黄虫丸对糖尿病小鼠具有降血糖作用。

Abstract

Objective: To study the hypoglycemic effect of Dahuang Zhechong Pill on alloxan-induced diabetic mice. Methods: We made up animal models of diabetic mice by intraperitoneal injection of 90 mg·kg-1 alloxan

the levels of glycated hemoglobin and lipids levels were measured. Mice were weighed before and after models made up. We anatomically separated the heart

liver

spleen

lung

kidney and thymus of the mice

weighed the organs and calculated the organ coefficient. Results: The level of blood glucose

glycated hemoglobin were increased

body weight and the weights of spleen

thymus were reduced after the models made up by introperitoneal injecting alloxan(90 mg·kg-1)on mice. Dahuang Zhechong Pill could reduce the level of blood glucose

glycated hemoglobin

increase level of high-density lipoprotein and improved the weight loss of the alloxan-induced diabetic mice

and increase the weights of spleen and thymus of immune organs. Conclusion: Dahuang Zhechong Pill has hypoglycemic effect on diabetic mice.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Studies on the Hypoglycemic Activity of Dahuang Zhechong Pill in Mice

Analysis on Changes of Chemical Composition Contents and Efficacy of Improving Insulin Resistance in Type 2 Diabetic Mice of Anemarrhenae Rhizoma Before and After Processing with Salt-water

Studies on Anti-hyperglycemic Effect of Ethanolic Extracts from (Retz.)Schult

Study of Jiangtang Xiaozhi Tablets on Decreasing of Blood Glucose in Rat and Mouse Models of Diabetes Mellitus

Hypoglycemic Activity of the Extracts from the Powder of in Type 2 Diabetic Mellitus Mice

Related Author

JI Min-chun

QIAN Qing-qing

QIAN Wei

SHEN Xiao-ying

YANG Yao-fang

Li YAN

Hui GAO

Wei ZHENG

Related Institution

The Fifth People’s Hospital of Shanghai Fudan University

（Chinese Materia Medica Processing Engineering and Technology Center of Liaoning Province， Key Laboratory of Processing Principle Analysis，National Administration of Traditional Chinese Medicine （TCM），School of Pharmacy，Liaoning University of TCM，，）

People’ Hospital of Wuxuan,Wuxuan

Department of Pharmacy,Guangxi Traditional Chinese Medical University

广西中医学院药学院广西南宁530001

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰