Objective: To investigate the Stachydrine (Sta) on norepinephrine (NE)-induced hypertrophy of neonatal rat cardiac myocyte sarcoplasmic reticulum calcium uptake capacity and activity of SERCA. Method: different concentrations of Stachydrine (10-4

10-5

10-6 mol/L) on the NE-induced cardiac hypertrophy model group intervention

by rat cardiac sarcoplasmic reticulum calcium uptake of protein levels and the ability to Stachydrine reflect on NE-induced hypertrophy of neonatal rat cardiac myocytes studied. Result: Stachydrine can significantly reduce the protein content of myocardial cells and reduce Protein / DNA ratio; Stachydrine in a dose-dependent increase NE-induced cardiac mast cells in sarcoplasmic reticulum calcium uptake and activity of SERCA. Conclusion: Stachydrine on NE-induced cardiac mast cells in sarcoplasmic reticulum calcium uptake have a certain degree of increased dose-dependent relationship between certain

with the concentration of Stachydrine improvement of sarcoplasmic reticulum calcium uptake rate and activity of SERCA has improved markedly.