Inhibitory Activity of  to -Glucosidase

CHEN Bai-quan; LI Chang-qin; CHANG Xing; KANG Wen-yi

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Inhibitory Activity of to -Glucosidase

更新时间：2024-01-04

- Inhibitory Activity of to -Glucosidase
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 8, Pages: 151-153(2010)
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- Published：2010
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CHEN Bai-quan, LI Chang-qin, CHANG Xing, et al. Inhibitory Activity of to -Glucosidase[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 151-153.
DOI：

CHEN Bai-quan, LI Chang-qin, CHANG Xing, et al. Inhibitory Activity of to -Glucosidase[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 151-153. DOI：

摘要

目的 :研究头花蓼不同溶剂提取物对 α -葡萄糖苷酶的抑制活性。方法 :采用索氏提取法对头花蓼进行不同溶剂提取

以体外法测定各提取物对 α- 葡萄糖苷酶的抑制作用。结果: 头花蓼各提取物均具有较好的 α -葡萄糖苷酶抑制活性。其中头花蓼的甲醇提取物抑制活性最高(IC50 1.68 μg·mL-1)

乙酸乙酯提取物(IC50 7.27 μg·mL-1)和石油醚提取物(IC50 116.81 μg·mL-1)的活性次之。3个提取物活性均远大于阳性对照acarbose(IC50 1 081.27 μg·mL-1)。且各提取物对 α- 葡萄糖苷酶的抑制作用均具有剂量依赖性。结论: 头花蓼甲醇提取物对 α- 葡萄糖苷酶活性的抑制效果非常显著

具有很好的开发价值。

Abstract

Objective: To investigate different extracts of Polygonum capitatum on inhibitory activity to α -glucosidase. Method: Different extracts were extracted by Soxhlet

and the inhibitory activity to α- glucosidase was screened by the 96-microplate-based method. Results: The results showed that P. capitatum had good inhibitory activity. The methanol extract had the highest inhibitory activity to α -glucosidase (IC50 1.68 μg·mL-1)

and then the ethyl acetate extract (IC50 7.27 μg·mL-1) and the petroleum ether extract (IC50 116.81 μg·mL-1)

three extracts of P. capitatum showed higher activity than Acarbose (IC50 1 081.27 μg·mL-1). And all of the extracts showed dose dependent for the inhibitory activity. Conclusion: The methanol extract of P. capitatum showed very significant inhibitory activity to α -glucosidase

and could be exploited the diabetes drugs as α- glucosidases inhibitors in future.

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