Antihypertensive Effects of Roots of  Extract in Renal Hypertensive Rats

CHAI Li-ming; TIAN Li; LI Yong; LIU Chun-sheng; WU Li-ya

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Antihypertensive Effects of Roots of Extract in Renal Hypertensive Rats

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- Antihypertensive Effects of Roots of Extract in Renal Hypertensive Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 11, Pages: 101-103(2010)
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- Published：2010
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CHAI Li-ming, TIAN Li, LI Yong, et al. Antihypertensive Effects of Roots of Extract in Renal Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 101-103.
DOI：

CHAI Li-ming, TIAN Li, LI Yong, et al. Antihypertensive Effects of Roots of Extract in Renal Hypertensive Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 101-103. DOI：

摘要

目的 :观察维药芹菜根醇提物对肾性高血压大鼠血压的影响并探讨其降压机制。方法: 建立两肾一夹(2K1C)肾性高血压模型

随机分为假手术组

模型组

阳性对照(卡托普利)组和维药芹菜根醇提物的高、中、低剂量组

按1次/d连续灌药16周

定期测定大鼠尾动脉收缩压和舒张压。末次给药后分离腹主动脉取血

测定超氧化物歧化酶(SOD)活力

丙二醛(MDA)

血管紧张素Ⅱ(AngⅡ)

内皮素(ET)含量。结果: 维药芹菜根醇提物组的SOD活力明显升高

MDA含量明显降低

血浆ET含量明显降低

其中高剂量组血浆中Ang-Ⅱ含量明显降低。结论: 维药芹菜根醇提物具有降低肾性高血压大鼠血压的作用。

Abstract

Objective: To observe the effects of aqueous extract of alcohol of the roots of Apium graveolens on blood pressure and underlying the mechanisms in renal hypertension rats. Method: Two-kidney one clip (2K1C) renal hypertension rats were randomly divided into negative control group

model group

the positive control (Captopril

CAP) group and the roots of A. graveolens extract high

medium low-dose group and

the daily perfusion for 16 week at any time adjust the dose according to weight capacity

periodic determination of rat tail artery systolic and diastolic blood pressure.After the last administration

after separation of the abdominal aorta blood

take heart

left ventricular weight (LVW) / body weight (BW) ratio

superoxide dismutase (SOD) activity

malondialdehyde (MDA)

vascular tone factor Ⅱ (Ang Ⅱ)

endothelin (ET) content. Result: The roots of A. graveolens extract L treatment group was significantly higher SOD activity

lower MDA content and significantly decreased plasma ET levels. The roots of A. graveolens plasma high-dose group were significantly lower Ang Ⅱ levels. Conclusion: The roots of A. graveolens extract can depress blood pressure in rats with renal hypertension.

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Related Author

CHAI Li-ming1

TIAN Li1

LI Yong1

LIU Chun-sheng2

WU Li-ya1

Ying-lan LIANG

Qiong ZHANG

KONG Xiang

Related Institution

College of Trditional Chinese Medicine,XinJiang Medical University

Beijing University of Traditional Chinese Medicine

People’s Hospital of Xinjiang Uygur Autonomous Region

Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University

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