Pharmacokinetics of Curcumin Microcystin in Rats

ZENG Xiao-hui; CHEN Yu-xing; ZHAO Zi-ming; HUANG Xue-jun; DU Tie-liang

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Pharmacokinetics of Curcumin Microcystin in Rats

更新时间：2024-09-23

- Pharmacokinetics of Curcumin Microcystin in Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 16, Issue 2, Pages: 107-110(2010)
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- Published：2010
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ZENG Xiao-hui, CHEN Yu-xing, ZHAO Zi-ming, et al. Pharmacokinetics of Curcumin Microcystin in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(2): 107-110.
DOI：

ZENG Xiao-hui, CHEN Yu-xing, ZHAO Zi-ming, et al. Pharmacokinetics of Curcumin Microcystin in Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(2): 107-110. DOI：

摘要

目的: 研究姜黄素微囊在大鼠体内的药代动力学过程。方法: 采用口服给药

进行颈动脉插管

分别于药后0.08

0.25

0.5

0.75

5.5 h采血

用HPLC进行检测。结果: 姜黄素微囊各剂量的药时曲线呈双峰现象;各剂量组的Cmax1和Cmax2分别为:高剂量(0.90 mg/L和1.20 mg/L)、中剂量(0.43 mg/L和0.46 mg/L)、低剂量(3.16 mg/L和1.31 mg/L);姜黄素微囊高、中、低3个剂量AUC分别为3.79

2.60

5.92 mg·h/L

低剂量比高中剂量的Cmax和AUC都大。结论: 姜黄素微囊在大鼠体内的药代动力学呈非线性过程

可能存在肠肝循环现象。

Abstract

Objective: To study the pharmacokinetics of curcumin microcystin in rats. Methods: The microcystin was orally administrated. After carotid artery cannulation

blood samples were collected after administration of 0.08

0.25

0.5

0.75

5.5 h

and tested by HPLC. Results: The various doses of curcumin concentration-time curve is bimodal; Cmax1 and Cmax2 of each dose group are as follows: high-dose(0.90

1.20 mg/L)

medium dose(0.43

0.46 mg/L)

low dose(3.16

1.31 mg/L); AUC are 3.79

2.60

5.92 mg·h/L respectively. Cmax and AUC of low dose are greater than that of the high and medium doses. Conclusion: The Pharmacokinetics of curcumin were nonlinear process in rat

there may be the phenomenon of enterohepatic circulation.

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Related Author

ZENG Xiao-hui

CHEN Yu-xing

ZHAO Zi-ming

HUANG Xue-jun

DU Tie-liang

XING Dong-ming1

ZHAO Yu-nan1

SHI Yue1

Related Institution

Guangdong Provincial Institute of Traditional Chinese Medicine

School of Life Sciences，Beijing University of Chinese Medicine

School of Pharmacy，Shanghai University of Traditional Chinese Medicine

School of Graduate Studies，Tianjin University of Traditional Chinese Medicine（TCM）

The Second Affiliated Hospital of Tianjin University of TCM

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