Effects of Shenfu Decoction, Qifu Decoction, Jiangfu Decoction on Cardiomyocyte Apoptosis Through Mitochondrion Signaling Pathway of Cardial Injury Model Induced by Adriamycin in Rat
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Effects of Shenfu Decoction, Qifu Decoction, Jiangfu Decoction on Cardiomyocyte Apoptosis Through Mitochondrion Signaling Pathway of Cardial Injury Model Induced by Adriamycin in Rat
Chinese Journal of Experimental Traditional Medical FormulaeVol. 16, Issue 8, Pages: 135-138(2010)
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Published:2010
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FAN Ying, CAI Li-ping, YU Cai-na, et al. Effects of Shenfu Decoction, Qifu Decoction, Jiangfu Decoction on Cardiomyocyte Apoptosis Through Mitochondrion Signaling Pathway of Cardial Injury Model Induced by Adriamycin in Rat[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 135-138.
DOI:
FAN Ying, CAI Li-ping, YU Cai-na, et al. Effects of Shenfu Decoction, Qifu Decoction, Jiangfu Decoction on Cardiomyocyte Apoptosis Through Mitochondrion Signaling Pathway of Cardial Injury Model Induced by Adriamycin in Rat[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(8): 135-138.DOI:
Effects of Shenfu Decoction, Qifu Decoction, Jiangfu Decoction on Cardiomyocyte Apoptosis Through Mitochondrion Signaling Pathway of Cardial Injury Model Induced by Adriamycin in Rat
Objective: To investigate the effect of Shenfu Decoction
Qifu Decoction
Jiangfu Decoction on cardiomyocyte apoptosis through the mitochondrion signaling pathway of cardial injury model induced by adriamycin in rat. Methods : Enzyme-linked immunosorbent assay(ELISA) was applied to measure the content of Caspase-9
Caspase-3
Bcl-2
Bax and cytochrome C in cardiomyocyte mitochondria. Results : In adryamycin-induced rat group: the content of Bcl-2 in myocardial mitochondria decreased
the content of Bax increased
the content of Caspase-9
Caspase-3 and cytochrome C increased
with statistical significance (P<0.05). In Shenfu Decoction group
Qifu Decoction group and Jiangfu Decoction group: the content of Bcl-2 in myocardial mitochondria increased
the content of Bax decreased
the content of Caspase-9
Caspase-3 and cytochrome C decreased
with statistical significance (P<0.05). Conclusion : There is relationship between the content of Caspase-9
Caspase-3
Bcl-2
Bax and cytochrome C and the ocurrence and development of adriamycin-induced cardial injury. Shenfu Decoction
Qifu Decoction
Jiangfu Decoction can protect myocardium by inhibiting adriamycin-induced cardiomyocyte apoptosis through the mitochondria signaling pathway.